Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Sickle cell trait is not risk factor for kidney disease

15.09.2011
Researchers at Wake Forest Baptist Medical Center report that sickle cell trait is not a risk factor for the development of severe kidney disease in African-Americans. This study, published in the August online issue of Kidney International, contradicts findings from a 2010 study that first suggested that having one copy of the sickle cell gene was a kidney disease risk factor.

Individuals with sickle cell trait inherit one sickle cell disease gene and one normal gene variant. Sickle cell trait usually does not have any of the symptoms of sickle cell disease and these individuals live a normal life. Seven to 9 percent of African-Americans in the United States have sickle cell trait.

"Although doctors have known for years that having two copies of the sickle cell gene puts people at an increased risk for developing kidney disease, the 2010 study was the first to suggest that having only one copy of this gene had the same result," said Barry I. Freedman, M.D., professor of nephrology and senior author of the Wake Forest Baptist study. "Had this been true, it would have had huge implications for public health, and caused concern for thousands of African-Americans with sickle cell trait."

Kidney disease is a growing public health problem, with approximately half a million individuals in the United States receiving dialysis treatments to replace the function of their failed kidneys. The problem is particularly problematic in African-Americans, whose rates of kidney disease are four times higher than those of European Americans.

Patients with sickle cell disease are known to develop kidney disease, including increased risk for end-stage kidney disease (ESKD) requiring dialysis, Freedman said.

Freedman's study assessed risk variants in 3,258 unrelated African-Americans from the southeastern United States. His study tested for a genetic association between sickle cell trait and common forms of ESKD in African-Americans.

No evidence of association between sickle cell trait and either diabetic or non-diabetic ESKD was detected in this large sample of African-Americans.

"Our results stand in contrast to a series of 188 patients with ESKD reported by Derebail (Journal of Society of Nephrology, 2010)," Freedman said. "Strengths of this new report include the large sample size, direct genotyping for sickle cell trait and adjustment for African ancestry, age and gender.

"We conclude that African-Americans with one copy of the sickle cell gene are not at increased risk for developing non-diabetic or diabetic end-stage kidney disease, relative to unaffected individuals."

Co-authors on this study were Pamela Hicks, Carl Langefeld, Ph.D., Lingyi Lu, Anthony Bleyer, M.D., Jasmin Divers, Ph.D., and Donald Bowden, Ph.D., from Wake Forest Baptist; and Vimal Derebail, M.D., and Patrick Nachman, M.D., from the University of North Carolina, Chapel Hill.

Media Contacts: Marguerite Beck, marbeck@wakehealth.edu, 336-716-2415; or Bonnie Davis, bdavis@wakehealth.edu, 336-716-4977.

Wake Forest Baptist Medical Center (www.wakehealth.edu) is a fully integrated academic medical center located in Winston-Salem, N.C. Wake Forest School of Medicine directs the education and research components, with the medical school ranked among the nation's best and recognized as a leading research center in regenerative medicine, cancer, the neurosciences, aging, addiction and public health sciences. Piedmont Triad Research Park, a division of Wake Forest Baptist, fosters biotechnology innovation in an urban park community. Wake Forest Baptist Health, the clinical enterprise, includes a flagship tertiary care hospital for adults, Brenner Children's Hospital, a network of affiliated community-based hospitals, physician practices and outpatient services. The institution's clinical programs and the medical school are consistently recognized as among the best in the country by U.S.News & World Report.

Marguerite Beck | EurekAlert!
Further information:
http://www.wakehealth.edu

More articles from Health and Medicine:

nachricht Electrical 'switch' in brain's capillary network monitors activity and controls blood flow
27.03.2017 | Larner College of Medicine at the University of Vermont

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Northern oceans pumped CO2 into the atmosphere

27.03.2017 | Earth Sciences

Fingerprint' technique spots frog populations at risk from pollution

27.03.2017 | Life Sciences

Big data approach to predict protein structure

27.03.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>