Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

EU project confirms Europe's excellence in migraine research

07.11.2007
An EU-funded project on migraines has not only taken researchers a step closer to understanding the causes of these incapacitating attacks, but has created a critical mass, reinforcing Europe's reputation of excellence in this field, and reassuring migraine sufferers that their condition is being taken seriously.

Over 12% of the world's population suffer from migraines, with women making up two-thirds of sufferers. The attacks are not only highly unpleasant for sufferers, but are also costly for employers and health services. Annual costs are estimated at €10 billion for the EU alone.

Although the problem is widespread, the available treatments are unsuccessful in more than half of patients. The migraine community is therefore desperate for possible treatments, and has demonstrated this by participating in EUROHEAD's research.

Coordinators of the recently-concluded EU-funded project EUROHEAD spoke to CORDIS News about the discoveries made in the project and the impact that it has had on the migraine research community worldwide.

A cure for migraines is still some way off, but the EUROHEAD team does now have a much better understanding of how genes are involved in the triggering of a migraine, and how the trigger threshold can be reduced.

There is compelling evidence that cortical spreading depression (CSD) is responsible for the 'aura', the visual disturbances that often accompany migraines. The EUROHEAD team now believes that it could also be responsible for the onset of migraines themselves.

Several thousand migraine patients participated in the research, including twins and families in which migraines are common. Crucial to the success of the project was the involvement of people who suffer from a monogenic subtype of migraine, in which one sole gene is responsible for the condition. Five or six years ago there was just one pool of patients with the monogenic migraine subtype. The EUROHEAD team has now identified far more families in which the condition runs, and has also identified new syndromes.

Much of the research was done using cellular models, but animal models and human volunteers were also involved. Cellular models enabled the team to see what effects the genes had on cells at microscopic level. When investigating how the cells interact, the animal models were needed. 'We could never have done this if we had stuck to single cells. The two models were complimentary,' explains Dr Arn van den Maagdenberg of Leiden University Medical Centre in the Netherlands.

Brave volunteers in Denmark had an attack triggered by a team at Glostrup University Hospital using nitric oxide. The method developed in Glostrup is successful in triggering migraines in 60% to 70% of sufferers. Asked about these volunteers' readiness to have a migraine triggered in the name of science, Principal Investigator Michel Ferrari was very positive: 'The migraine population as a whole is very happy with initiatives like this. They feel they are being taken seriously. It has been established that this is a real disease,' he says.

While EUROHEAD has shown migraine-sufferers that they are being taken seriously, it has also indicated to the world that Europe should be taken seriously as a centre of excellence for migraine research. 'Europe is already the centre of excellence for migraine research. It is striking that, in other medical areas, the US is leading, but not in this area,' says Dr Ferrari. Moreover, most of the important research groups in this field were members of the EUROHEAD consortium.

The team has been contacted by researchers in every continent interested in collaborating on future research. Many have even sent genetic material from new families of migraine-sufferers. The EUROHEAD team is following up on the invitations that it has received, and many joint publications are in the pipeline.

EUROHEAD is currently experiencing what Dr van den Maagdenberg refers to as the 'magnet effect'. 'Everybody's looking at EUROHEAD as the experts on migraines,' he said.

Dr van den Maagdenberg welcomes the critical mass, the integration of research teams and the momentum created by EUROHEAD. When the right call is published under the EU's Seventh Framework Programme (FP7), the team will apply for further funding with the ultimate aim of finding a cure for the migraine.

Virginia Mercouri | alfa
Further information:
http://www.eurohead.org/
http://cordis.europa.eu/news

More articles from Health and Medicine:

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>