Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Umeå scientist presents discoveries about natural immunity in Science

05.03.2002


A team including scientists at UCMP (Umeå Center for Molecular Pathogenesis), a research unit at Umeå University, shows in last week’s issue of the journal Science that the protein PGRP-LC plays a crucial role in so-called innate immunity.



Professor Dan Hultmark, post-doctoral fellow Svenja Stöven, and doctoral candidate Thomas Werner at UCMP are focusing their attention on the mechanisms behind natural, or innate, immunity, and they are using the fruit-fly, Drosophila melanogaster, as a model system. The aim is, one the one hand, the better to understand the corresponding system in humans and, on the other hand, the fact that immunity in insects is itself important, mainly because a large number of diseases are spread by insect vectors.

When insects are infected by bacteria or fungi they react by producing effective antidotes in the form of special proteins and peptides that kill the invaders. This natural immune defense is triggered by substances from the invaders’ cell walls.


One such triggering factor is peptidoglycan, but little has been known about just how it is recognized by the immune defense system. In this article the UCMP team, in collaboration with researchers from the Sloan-Kettering Institute and Cornell University, have been able to show that the protein PGRP-LC plays a key role. They found that this protein switches on the immune defense system by activating a transcription factor, “Relish,” which was previously discovered by Dan Hultmark’s team. PGRP-LC belongs to a family of “PEPTIDOGLYCAN Recognition Proteins” (PGRP) that bind to peptidoglycan. PGRP was first discovered in butterflies, and interestingly enough there is an equivalent in humans as well.

Hans Fällman | alphagalileo

More articles from Health and Medicine:

nachricht Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University

nachricht ASU scientists develop new, rapid pipeline for antimicrobials
14.12.2017 | Arizona State University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Plasmonic biosensors enable development of new easy-to-use health tests

14.12.2017 | Health and Medicine

New type of smart windows use liquid to switch from clear to reflective

14.12.2017 | Physics and Astronomy

BigH1 -- The key histone for male fertility

14.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>