A large study published today in the journal Critical Care recommends that clinicians should strictly control calorie intake, start artificial nutrition within 24 hours and regularly monitor liver function in patients at high risk. The researchers find that patients given enteral nutrition were less likely to suffer from liver dysfunction than those fed through a central venous catheter. Liver dysfunction was more frequent in patients who had sepsis on admission or were fed more than 25kcal/kg a day.
The study was conducted by Teodoro Grau, from the Hospital Severo Ochoa in Madrid, Spain, and colleagues from hospitals in Spain and London, UK. The researchers looked at incidence of liver dysfunction associated with artificial nutrition in 40 intensive care units (ICU) in Spain. Patients were followed until hospital discharge or 28 days after ICU admission. Of 3,409 patients in the study, 725 received artificial nutrition. Of these, 303 received total parental nutrition (TPN) via a central venous catheter, while 422 were given enteral nutrition (EN) through a nasogastric or nasojejunal tube, at the doctor’s discretion. 23% (166) of all patients who received artificial nutrition developed liver dysfunction. Rates of liver dysfunction were higher in the TPN group (30%) than in the EN group (18%).
The researchers found that patients who were suffering from sepsis and treated with TPN were at a greater risk of liver dysfunction. Patients receiving TPN were also less nourished.
Liver dysfunction was associated with a longer stay in the ICU and in hospital, but did not increase mortality. Patients who were fed early in their stay had significantly lower incidence of liver dysfunction.
Grace Baynes | alfa
Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania
The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
17.01.2017 | Earth Sciences
17.01.2017 | Materials Sciences
17.01.2017 | Architecture and Construction