WellBeing of Women has awarded Miss Esther Moss at Keele University a Research Training Fellowship of over £101,500 to identify the specific genes involved in chemotherapy resistance in ovarian cancer. Funds for the research were raised by the generous support of the general public during the charity’s annual ovarian cancer awareness campaign, which has run for the past four years.
Ovarian cancer is currently diagnosed in almost 7,000 women in the UK each year. Despite advances in surgical techniques and chemotherapy treatments, very few women with ovarian cancer will survive long-term - the 5-year survival rate is around 30% (compared with 70% for breast cancer). Chemotherapy is an effective initial treatment for late stage ovarian cancer with approximately 70-80% of patients experiencing a reduction in the size of the cancer (partial response), or the disappearance of the cancer (complete response).
Carboplatin used in chemotherapy for ovarian cancer, kills tumour cells by forcing them to undergo programmed cell death (apoptosis). However these effects are not sustained and the majority of tumours will recur due to the growth of drug resistant cancer cells, which escape apoptosis. Previous research has shown that there are differences in gene expression, between cancer cells killed by the chemotherapy, and those that are able to survive.
Commenting of the study, Miss Esther Moss said, ”The primary outcome of this research will be to identify genes whose function, when disrupted, leads to chemo resistance in ovarian cancer. Identification of the genes involved in resistance to chemotherapy might provide biomarkers to aid in the conventional management of patients, and may also lead to the development of novel mechanism-based therapies for ovarian cancer.”
The charity’s Director, Liz Campbell said; “These awards are particularly important in encouraging medical graduates to pursue obstetrics and gynaecology at a time when different specialties are competing for the brightest and best. Research Training Fellowships are just one way that WellBeing of Women makes a valuable contribution to the development of tomorrow’s innovative medical leaders.”
Chris Stone | alfa
New study points the way to therapy for rare cancer that targets the young
22.11.2017 | Rockefeller University
Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine
Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
23.11.2017 | Information Technology
23.11.2017 | Physics and Astronomy
23.11.2017 | Life Sciences