WellBeing of Women has awarded Miss Esther Moss at Keele University a Research Training Fellowship of over £101,500 to identify the specific genes involved in chemotherapy resistance in ovarian cancer. Funds for the research were raised by the generous support of the general public during the charity’s annual ovarian cancer awareness campaign, which has run for the past four years.
Ovarian cancer is currently diagnosed in almost 7,000 women in the UK each year. Despite advances in surgical techniques and chemotherapy treatments, very few women with ovarian cancer will survive long-term - the 5-year survival rate is around 30% (compared with 70% for breast cancer). Chemotherapy is an effective initial treatment for late stage ovarian cancer with approximately 70-80% of patients experiencing a reduction in the size of the cancer (partial response), or the disappearance of the cancer (complete response).
Carboplatin used in chemotherapy for ovarian cancer, kills tumour cells by forcing them to undergo programmed cell death (apoptosis). However these effects are not sustained and the majority of tumours will recur due to the growth of drug resistant cancer cells, which escape apoptosis. Previous research has shown that there are differences in gene expression, between cancer cells killed by the chemotherapy, and those that are able to survive.
Commenting of the study, Miss Esther Moss said, ”The primary outcome of this research will be to identify genes whose function, when disrupted, leads to chemo resistance in ovarian cancer. Identification of the genes involved in resistance to chemotherapy might provide biomarkers to aid in the conventional management of patients, and may also lead to the development of novel mechanism-based therapies for ovarian cancer.”
The charity’s Director, Liz Campbell said; “These awards are particularly important in encouraging medical graduates to pursue obstetrics and gynaecology at a time when different specialties are competing for the brightest and best. Research Training Fellowships are just one way that WellBeing of Women makes a valuable contribution to the development of tomorrow’s innovative medical leaders.”
Chris Stone | alfa
Investigators may unlock mystery of how staph cells dodge the body's immune system
22.09.2017 | Cedars-Sinai Medical Center
Monitoring the heart's mitochondria to predict cardiac arrest?
21.09.2017 | Boston Children's Hospital
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
22.09.2017 | Life Sciences
22.09.2017 | Medical Engineering
22.09.2017 | Physics and Astronomy