Untreated diabetic leg ulcers may result in amputations.
According to the Center of Disease Control, one out of six diabetics will require an amputation (below the knee) during their lifetime.
A study published in the July journal of Clinical and Applied Thrombosis/Hemostasis shows that Pycnogenol® (pic-noj-en-all), an antioxidant plant extract from the bark of the French maritime pine tree, heals leg ulcers in patients who suffer from diabetic leg ulcerations. The most significant findings were patients treated with oral and local Pycnogenol® resulting in a 74.4 percent decrease in ulcer size within six weeks.
According to Dr. Gianni Belcaro, a lead researcher of the study, the majority of diabetic leg amputations common to the lower leg and feet, begin with the formation of skin ulcers. Impaired blood circulation in diabetics may cause tissue necrotization and discoloration which leads to development of ulcers. The open ulcer is prone to infection and difficult to heal.
The study sampled thirty diabetic patients at the Chieti-Pescara University in Italy, who suffer from severe microangiopathy causing leg ulcerations. Patients were randomly assigned to four groups. Treatment was provided daily for six weeks.
After six weeks of treatment results showed the most significant ulcer healing for patients who supplemented with combined oral and local treatment. Group 1 patients supplemented with oral and local Pycnogenol® experienced a 74.4 percent decrease in leg ulcer size. Group 2 patients supplemented with local Pycnogenol® experienced a 41.3 percent decrease in leg ulcer size. Group 3 patients supplemented with oral Pycnogenol® experienced a 33 percent decrease in leg ulcer size. Group 4, the control group, experienced a 22 percent decrease, from disinfecting the ulcers on a daily basis. Eighty-nine percent of the patients treated with oral and local Pycnogenol® were completely healed.
Group 1 participants received 150 mg Pycnogenol® as oral treatment and 100 mg from capsules as powder placed on the ulcerated area (local); Group 2 participants received oral treatment Pycnogenol® with 150 mg; Group 3 received 100 mg of local treatment and Group 4 received no medical care, other then the same ulcer care as the other subjects (washed and cleaned with warm water and local disinfectant).
Ulcers were washed and medicated every day for six weeks. The area of the ulceration was copied on a transparent plastic sheet and the relative integral was recorded in a computerized system. A microcirculatory evaluation was performed at inclusion of the study and repeated after six weeks.
Direct questioning was used to evaluate tolerability and compliance, particularly gastrointestinal problems, systematic and local skin alterations, signs of allergic reaction and any other manifestation. No side effects were reported.
Over 35 years of research on Pycnogenol® demonstrate the antioxidant's ability to improve blood flow, encouraging improved circulation. "The Pycnogenol®-treated groups all showed a significantly increased oxygen presence in the skin and a significantly lowered carbon dioxide level. These findings suggest that Pycnogenol® helps to resolve the underlying microangiopathy with an improved blood micro-circulation carrying more oxygen to the feet," said Dr. Belcaro. "Better circulation decreases the chance of developing ulcers."
Previous research shows Pycnogenol® may be helpful in controlling an array of problems prevailing in diabetics. Clinical studies which sampled more than 1,200 patients demonstrated Pycnogenol® treatment to be highly effective for prevention of diabetic retinopathy--bleeding capillaries in the eye that causes irreversible vision loss. Other studies show Pycnogenol to be effective in lowering glucose levels and increasing the health of blood vessels in patients with type II diabetes, after supplementation of 50–200 mg Pycnogenol.
"If left untreated, damage to blood vessels from diabetes then manifests in typical circulatory problems such as hypertension, from which 50 percent of type II diabetics suffer. Solid evidence shows that Pycnogenol® effectively reduces high blood pressure, platelet aggregation, LDL cholesterol and enhances circulation," said Belcaro.
Melanie Nimrodi | EurekAlert!
New study points the way to therapy for rare cancer that targets the young
22.11.2017 | Rockefeller University
Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine
Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
23.11.2017 | Information Technology
23.11.2017 | Physics and Astronomy
23.11.2017 | Life Sciences