Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers demonstrate potential mechanism of food allergy

24.07.2006
Study shows interaction of proteins in the intestinal system may be allergic indicators

Researchers have identified one of the proteins that may be responsible for causing food allergies, which could lead to the development of more accurate non-invasive tests to identify true food allergies, according to a study published in the July issue of Gastroenterology, the journal for the members of the American Gastroenterological Association.

Food allergies often present a unique problem for allergy testing since not every patient has detectable levels of immunoglobulin E (IgE) in their serum, especially patients with delayed allergies. A number of reliable testing methods exist for food and other allergies, including skin tests and serum IgE tests, however, they may not accurately diagnose food allergies. The oral food challenge is considered the most accurate test for food allergies but is expensive to administer and has to be done in a controlled environment. Immunoglobulin (antibody) E is a protein produced by plasma cells (or B-Cells , a type of lymphocyte ), which is designed to control the immune response in extracellular fluids by binding to substances in the body that are recognized as foreign.

The study, conducted at the Mount Sinai School of Medicine, New York, showed for the first time that CD23, a protein normally expressed in a person's intestinal tract, acts as a receptor for IgE, a protein associated with allergic reactions, and enables it to participate in food-allergic reactions.

"We believe that the presence of CD23 may provide a surrogate method of looking at the gut without invasive tests like biopsies," according to M. Cecilia Berin, PhD, assistant professor, pediatrics/allergy and immunology, Mount Sinai and lead author of the study.

Results of this study showed that CD23 was detectable in stool samples from food allergic patients, but not the controls, suggesting either increased levels of CD23 on intestinal cells or an allergen-induced shedding of CD23 in food allergic patients. Additionally, researchers found a strong correlation between the level of CD23 and food-specific IgE in the stool, demonstrated by the availability of IgE antibodies to interact with CD23 on the outside surface of the gastrointestinal wall.

Researchers collected stool samples from nine pediatric patients (age range three to 17 years) who underwent an oral food challenge, during which they were administered either egg or milk in a controlled environment. All patients had a history of allergies to these foods and had reacted positively through other testing methods. Their symptoms, which occurred less than two hours after the food challenge, included skin reactions, breathing problems and gastrointestinal problems or a combination. They were matched to five pediatric controls with no food allergies.

"Based on the results of our study, we intend to conduct larger scale trials of patients with food allergic disorder to determine how CD23 in the stool correlates with clinical findings," according to Dr. Berin. "We hope to determine that CD23 offers a promising target for food allergies that leads to more accurate, easier to tolerate tests for these patients."

Food allergies affect an estimated six to eight percent of American children age four years or younger and approximately two percent of adults, according to the National Institute of Allergy and Infectious Diseases (NIAID). The study authors estimate that three and a half to four percent of these food allergies are IgE-mediated. While many people believe they have food allergies, the majority of individuals experience food intolerance.

Food allergies are an exaggerated immune response in which the body produces histamines and antibodies that induce symptoms in the gastrointestinal tract, airways and skin, and in the most severe cases induces anaphylactic shock, an often fatal systemic reaction. These allergies are often characterized by abdominal pain, diarrhea, vomiting, hives, swelling of the eyelids, face, lips and tongue, shortness of breath or wheezing and difficulty swallowing, among other symptoms. The most common allergens are peanuts, tree nuts, shellfish, fish, wheat, milk, eggs and soy.

Aimee Frank | EurekAlert!
Further information:
http://www.gastro.org

More articles from Health and Medicine:

nachricht Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>