Pre-eclampsia kidney disease link
Pre-eclampsia is a complication in pregnancy occurring in approximately eight percent of all pregnancies. It is characterised by elevated blood pressure and protein in the urine. It generally develops after 20 weeks of pregnancy.
Medical doctor and researcher Bjoern Egil Vikse from the Department of Medicine at University of Bergeb is the first author of an upcoming article in the March issue of the Journal of the American Society of Nephrology.
Vikse explains that there were two reasons for becoming involved in this work. The first was that a collegaue had previously found a strong correlation between pre-eclampsia and a later incidence of cardiovascular disease. The second is that UiB researchers have a unique research tool. They have access to two large databases: one is a birth registry; the other is a kidney biopsy registry. This enables them to use large, well-documented data pools in their work.
The Birth Registry provided Vikse with data from 1967 and the Kidney Biopsy Registry dates from 1988.
Unexpectedly strong correlation
Vikse and his colleagues first compared data from the two registries to see if there was a correlation between the children of mothers who had experienced pre-eclampsia and incidence of kidney disease in these children. They found no correlation.
They then compared the two databases for a possible correlation between the incidence of pre-eclampsia and later incidence of kidney disease in the mothers and found an unexpectedly strong result.
-We were amazed that the correlation was so strong," says Vikse. The data showed that pre-eclampsia alone was responsible for the mothers having a 3.3% increased risk of developing kidney disease later. If, in addition, the child had a low birth weight, the risk increased to a 4.8% increased risk with low birth-weight and a dramatic17% increased risk with very low birth-weight.
Another unexpected finding was that the increased risk was not associated with any particular kidney disease: all kidney diseases had a similar increased risk.
-You would expect the risk increase to be linked to a particular disease," explains Vikse. "It was most unusual to find that this was not the case."
Vikse explains that the researchers will now try to characterise the correlation further as well as checking for correlations with other medical conditions such as kidney failure. Studies into the development of both pre-eclampsia and kidney disease are also needed to see if there are any similarities between the mechanisms by which both medical conditions develop.
According to Vikse, there are also more far-reaching consequences as well. This result suggests that information about having experienced a pregnancy with pre-eclampsia should be included in a womans medical history record. Such women need to be followed up for the rest of their lives because of their increased risk of cardiovascular and kidney disease.
Bjorn Egil Vikse | alfa
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...