Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Drug-ultrasound combination increases reopening of blocked arteries after stroke

17.02.2006


Preliminary result of IMS-II study presented at International Stroke Conference



Standard clot-busting medication combined with low-energy ultrasound appears to reopen clogged arteries in stroke patients better than medication alone, a pilot study led by University of Cincinnati researchers shows.

The findings, says the University of Cincinnati’s Joseph Broderick, MD, co-principal investigator of the study, are encouraging and support a much broader phase-3 trial planned to begin soon.


Dr. Broderick, chair of the neurology department at the University of Cincinnati (UC) and co-principal investigator Thomas Tomsick, MD, director of neuroradiology at UC and Cincinnati’s University Hospital, presented their findings today at the International Stroke Conference in Kissimmee, Fla. The study was co-sponsored by the National Institute of Neurological Disorders and Stroke (NINDS) and EKOS Corporation.

The study, known as Interventional Management of Stoke Study or IMS-II, involved 73 participants between the ages of 18 and 80 treated in 13 participating centers and suffering from severe ischemic stroke. Each was given lower than standard doses of tissue plasminogen activator (tPA) during a 30-minute period within three hours of the onset of stroke.

Subjects were then immediately taken for an angiography where a microcatheter (small tube) was placed into a groin artery and threaded to the site of the blocked artery in their brain. Twenty-one participants without a visible and treatable clot received no additional therapy. The remainder of participants (52) who had visible, treatable clots was treated with up to 22 milligrams of additional tPA delivered through the catheter directly to the blockage.

Whenever possible, they were also given a low-energy ultrasound treatment at the site of the clot. The ultrasound, which attempted to break up the clot, was administered using the EKOS Micro-Infusion Catheter MicroLysus infusion system. In 18 participants, where the EKOS MicroLysus catheter could not access the clot, a standard catheter was used to deliver tPA to the clot site.

Partial or complete reopening of the blocked brain artery occurred in 69 percent of the 34 patients receiving the ultrasound treatment. This was an improvement when compared with the IMS-I study, in which 55 percent of patients involved achieved partial or complete reopening of the blocked artery. The IMS-I study used only a microcatheter to deliver tPA directly to the location of the stroke-causing clot.

"After adjustment for differences in baseline stroke severity, age and time-to-treatment, the likelihood of IMS-II subjects attaining functional independence at three months was 65 percent relatively greater compared to IV-only tPA-treated subjects in IMS-I," Dr. Broderick says.

The mortality of the IMS-II participants (16 percent) was identical to those in IMS-I. Participants in the earlier NINDS tPA Stroke Trial, which tested the benefit of tPA administered within three hours after onset of stroke, had a 21 percent mortality. Dr. Broderick noted, however, that the rate of bleeding in the brain that resulted in worsening of the participants’ condition during the IMS-II study was 11 percent as compared to 6.3 percent in the IMS-I study.

"A combined analysis of IMS I and II studies to investigate the effect of treatment on patient outcome, reopening of arteries, and safety is being planned," says Dr. Broderick.

Strokes affect about 600,000 Americans each year and are the third leading cause of death in the United States after heart disease and cancer. There are two main types of stroke: ischemic, which results from blockage of a blood vessel, and hemorrhagic, which is caused by bleeding.

Quickly reopening clogged brain arteries in stroke patients is important because the longer the blood supply to the brain is blocked, the more likely long-lasting brain damage will occur.

"Stroke studies such as the IMS are advancing our knowledge about stroke so that ultimately more lives may be spared," Dr. Broderick says. "More importantly, quality of life is preserved by preventing the debilitation that comes with permanent brain damage."

Sheryl Hilton | EurekAlert!
Further information:
http://www.uc.edu

More articles from Health and Medicine:

nachricht Minimising risks of transplants
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

nachricht FAU researchers demonstrate that an oxygen sensor in the body reduces inflammation
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

The RWI/ISL-Container Throughput Index started off well in 2018

22.02.2018 | Business and Finance

FAU researchers demonstrate that an oxygen sensor in the body reduces inflammation

22.02.2018 | Health and Medicine

Histology in 3D: new staining method enables Nano-CT imaging of tissue samples

22.02.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>