The risk for a new cancer in the unaffected breast substantially increases in women diagnosed with unilateral, hereditary (non-BRCA1/2) breast cancer, according to a new study by researchers working at Karolinska Institutet in Stockholm, Sweden. The study is the first in its kind and is published in the March 15, 2006 issue of CANCER.
Women with hereditary (non-BRCA1/2) breast cancer are estimated to be at up to six times greater risk of developing a second primary malignancy in the other breast, also known as contralateral breast cancer (CBC), than the general population is of developing primary breast cancer. Young age at first diagnosis, family history of breast cancer, and confirmed BRCA1 or BRCA2 gene mutations are the primary risk factors for CBC. However, the contribution of non-BRCA1/2 hereditary cancers to the risk of CBC is poorly understood.
A group of researchers at Karolinska Institutet and Umeå Universitet in Sweden reviewed data from 120 families and 204 women with unilateral breast cancer and a family history of breast cancer but no BRCA mutations to better characterize the CBC risk for these women.
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