Mount Sinai School of Medicine researchers discovered Alzheimers patients with lifetime history of depression have more rapid cognitive decline
A lifetime history of depression is associated with increased plaques and tangles in the brains of those with Alzheimers disease and more rapid cognitive decline, according to a study by researchers at the Alzheimers Disease Research Center at Mount Sinai School of Medicine. The study is published in the February issue of Archives of General Psychiatry, one of the JAMA/Archives journals.
Previous studies have linked depression and Alzheimers disease, according to background information in the article. People with a lifetime history of major depressive disorder (MDD) may be more likely to be diagnosed with AD. In addition, both AD and MDD are likely to affect the brains memory-related temporal lobes. MDD is likely to caused atrophy of the hippocampus, the area where the largest amounts of plaques and tangles form in patients with AD, the authors write.
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