Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Hopkins study finds no ’cognitive decline’ after use of heart-lung machine during bypass surgery


Controlled study should reassure patients

The use of a cardiopulmonary heart pump during coronary artery bypass grafting (CABG) surgery does not significantly damage such high-level mental tasks as thinking, reasoning and remembering, according to a study by Johns Hopkins researchers recently published in Neurology.

CABG surgery is effective for the relief of angina and reducing the risk of a heart attack but has been widely feared to cause "pump-related" damage to the cerebral cortex, according to Guy M. McKhann, M.D., a professor in the Department of Neurology at The Johns Hopkins University School of Medicine.

To gauge whether there was a clinical basis for this concern, McKhann led a non-randomized study comparing the cognitive abilities of on-pump CABG patients, off-pump CABG patients, nonsurgical patients with coronary artery disease and heart- healthy individuals. The results of the study showed that on-pump CABG patients had no significant differences in their higher-level mental functions than the other groups tested, according to McKhann.

"This outcome should be reassuring to both patients and surgeons engaged in on-pump CABG surgeries," McKhann said.

The study, conducted between September 1997 and September 2003, involved 380 individuals -- 140 on-pump CABG patients, 72 off-pump CABG patients, 99 nonsurgical patients with coronary artery disease and 69 heart-healthy patients.

Both the on-pump CABG patients and the nonsurgical patients with coronary artery disease were exclusively Hopkins-based, whereas the off-pump CABG patients came from Hopkins; Sinai Hospital, Baltimore, Md.; Washington Adventist Hospital, Takoma Park, Md.; University of Maryland Medical Center, Baltimore, Md., and Pinnacle Health System, Harrisburg, Pa.

Study participants were given a battery of standardized neuropsychological tests that were repeated three months and 12 months later.

Test scores were sorted and combined into eight areas: verbal memory, visual memory, language, attention span, visuoconstruction (the ability to copy a complex figure), motor speed (the time to perform motor activity, such as writing the alphabet), psychomotor speed (the time to complete an action that requires some planning) and executive function (the ability to plan ahead and make judgments).

The Center for Epidemiologic Studies Depression scale (CESD) and Functional Status Questionnaire (FSQ) were also administered at baseline and follow-up and all subjects were tested by the same team of study investigators who traveled to all the sites in the study to examine patients. Previous test results were not reviewed before subsequent testing so that testers were unlikely to be able to bias results based on such knowledge.

Self-reporting of well-being was included in the study in the areas of memory, mental arithmetic, personality, and reading newspapers and books. For example, subjects were asked whether they thought their personality had improved, changed for the worse, or stayed the same over time and since the previous interview. Reading, defined as whether or not a patient typically read either newspapers or books, was assessed at each visit.

At the start of the study, subjects with coronary artery disease (CABG on-pump, CABG off-pump, and nonsurgical) had overall lower performance than the heart-healthy group in several cognitive domains. But by three months, all groups had improved, which McKhann says was most likely due to familiarization with the testing procedures. Between three and 12 months, there were minimal changes in individual subjects for all groups, and no consistent differences between the CABG and off-pump patients were observed.

"These results offer no evidence that the cognitive test performance of on-pump CABG patients differed from that of off-pump control groups with coronary artery disease over a one-year period," McKhann said.

Eric Vohr | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>