Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Emotional impairment linked to cognitive deficits in bipolar children

21.10.2005


Researchers at the University of Illinois at Chicago used functional brain imaging to establish a link between emotional impairment and poor cognition in children with bipolar disorder.



"This study is very exciting because it shows that negative emotions affect cognition differently than positive emotions in these kids," said Dr. Mani Pavuluri, associate professor of psychiatry at UIC’s Institute for Juvenile Research and the Center for Cognitive Medicine, and lead author of the study.

Using functional magnetic resonance imaging, Pavuluri and her colleagues examined the brain activity of teens while they were performing certain mental tasks. The researchers scanned the brains of 10 unmedicated bipolar patients with normal mood and compared them with 10 healthy subjects of the same age and gender.


The children, aged 12 to 18, were asked to match positive or negative words with colors to determine how stimuli impact different areas of the brain responsible for emotion and cognition.

When shown negative words, compared to neutral words, the bipolar patients showed increased activation in the part of the brain that regulates emotions. When shown positive words, they showed activation in the reward centers of the brain which are often associated with pleasure and addiction.

In healthy subjects, positive and negative words activated the regions of the brain associated with cognitive behavior such as thinking, reasoning and learning.

"We found that the amygdala, the part of the brain that is supposed to react to emotional stimuli, is over-reactive to negative stimuli in children with bipolar disorder," said Pavuluri. "And the part of the brain that controls cognitive behavior is under-reactive."

Results of the study will be presented Oct. 20 at 2 p.m. at a joint meeting of the American Academy of Child and Adolescent Psychiatry and the Canadian Academy of Child and Adolescent Psychiatry in Toronto.

Pavuluri says the findings have direct clinical implications for present and future medication trials and cognitive behavioral therapy used to treat children with bipolar disorder.

Pediatric bipolar disorder, also known as manic depression, is associated with sexual promiscuity, failure in school, addiction and suicide. The disorder is characterized by extreme changes in mood and is often misdiagnosed. Patients may alternate between depression and euphoria, or mania.

Other UIC researchers in the study were Subhash Aryal, Megan O’Connor, Erin Harral, Ellen Herbener, and senior collaborator John Sweeney.

Sherri McGinnis Gonzalez | EurekAlert!
Further information:
http://www.uic.edu

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>