Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Vanadium appears to play role in speeding recovery from infections

12.10.2005


Dietary supplements containing vanadium are used by body builders to help beef up muscles and by some diabetic people to control blood sugar. New research now suggests the naturally occurring but easily toxic element may help prepare the body to recover speedily from infections from gram-negative organisms such as E. coli.



In research at the University of Illinois at Urbana-Champaign, scientists are trying to understand how recovery might be encouraged and why people with diabetes tend to have lingering behavioral symptoms such as fatigue and apathy long after many infections end.

Their latest research found that mice given vanadium -- in its typical vanadyl sulfate form -- before exposure to a pathogen sped recovery in both diabetic and non-diabetic animals. They also tested pre-treatment with insulin-like growth factor (IGF-1), which vanadium mimics, but only the non-diabetic mice recovered quickly after exposure.


The new paper appeared on line Oct. 10 ahead of regular journal publication in the Proceedings of the National Academy of Sciences.

Researchers Daniel R. Johnson, a doctoral student, and Dr. Gregory Freund, head of the pathology department in the College of Medicine at Urbana-Champaign, don’t suggest adding vanadium supplements to everyday diets. However, they said, the findings raise questions about just how it works and how it might be useful in speeding recovery.

The amount of vanadium used in the study was comparable to that found in nutritional supplements. While its nutritional value is unclear, the body needs an estimated 10 to 20 micrograms a day and obtains it mostly from plant material. Vanadium in much higher levels becomes toxic. Its use for building muscles has not been confirmed, but vanadium has improved insulin sensitivity and reduced blood sugar in diabetic people.

In their research, Johnson first administered a low dose of lipopolysaccharide (LPS), a molecule present on E. coli and other gram-negative bacteria, to both diabetic and non-diabetic mice after they had been given IGF-1. Non-diabetic mice recovered more quickly than diabetic mice, suggesting, he said, an insulin resistance state in the diabetic animals.

Next, experimental mice were pre-treated with vanadyl sulfate before exposure to LPS. Recovery after illness of the vanadium-treated mice, diabetic or not, was 50 percent faster than that of the untreated control mice.

"With vanadyl sulfate being like IGF-1, we expected to see resistance in the diabetic animals, but we didn’t see that," Johnson said. "We saw similar improvement. Thus it must have been acting through a different pathway than do IGF-1 or insulin."

Johnson and Freund, also an adjunct professor of animal sciences and a researcher in the immunophysiology and behavior program at Illinois, theorize it may be vanadium’s metal-related shape or its ability to inhibit tyrosine phosphatases, which help to modulate signaling proteins, in the immune system. Freund and colleagues last year documented a connection between serine phosphorylation and anti-inflammatory cytokines.

"Diabetes affects millions of people," Freund said. "It is hard to overcome many of the problems in a nutritionally dependent fashion. This research implies that metals that are trace elements may have more importance than we realize to human health, not only in preventing diseases but also in making you feel better."

It’s possible, Johnson said, that taking vanadyl-sulfate-containing supplements beginning two weeks before possible exposure to gram-negative organisms might help speed recovery from subsequent infection.

Jim Barlow | EurekAlert!
Further information:
http://www.uiuc.edu

More articles from Health and Medicine:

nachricht Antibiotic effective against drug-resistant bacteria in pediatric skin infections
17.02.2017 | University of California - San Diego

nachricht Tiny magnetic implant offers new drug delivery method
14.02.2017 | University of British Columbia

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Biocompatible 3-D tracking system has potential to improve robot-assisted surgery

17.02.2017 | Medical Engineering

Real-time MRI analysis powered by supercomputers

17.02.2017 | Medical Engineering

Antibiotic effective against drug-resistant bacteria in pediatric skin infections

17.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>