Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Vanadium appears to play role in speeding recovery from infections

12.10.2005


Dietary supplements containing vanadium are used by body builders to help beef up muscles and by some diabetic people to control blood sugar. New research now suggests the naturally occurring but easily toxic element may help prepare the body to recover speedily from infections from gram-negative organisms such as E. coli.



In research at the University of Illinois at Urbana-Champaign, scientists are trying to understand how recovery might be encouraged and why people with diabetes tend to have lingering behavioral symptoms such as fatigue and apathy long after many infections end.

Their latest research found that mice given vanadium -- in its typical vanadyl sulfate form -- before exposure to a pathogen sped recovery in both diabetic and non-diabetic animals. They also tested pre-treatment with insulin-like growth factor (IGF-1), which vanadium mimics, but only the non-diabetic mice recovered quickly after exposure.


The new paper appeared on line Oct. 10 ahead of regular journal publication in the Proceedings of the National Academy of Sciences.

Researchers Daniel R. Johnson, a doctoral student, and Dr. Gregory Freund, head of the pathology department in the College of Medicine at Urbana-Champaign, don’t suggest adding vanadium supplements to everyday diets. However, they said, the findings raise questions about just how it works and how it might be useful in speeding recovery.

The amount of vanadium used in the study was comparable to that found in nutritional supplements. While its nutritional value is unclear, the body needs an estimated 10 to 20 micrograms a day and obtains it mostly from plant material. Vanadium in much higher levels becomes toxic. Its use for building muscles has not been confirmed, but vanadium has improved insulin sensitivity and reduced blood sugar in diabetic people.

In their research, Johnson first administered a low dose of lipopolysaccharide (LPS), a molecule present on E. coli and other gram-negative bacteria, to both diabetic and non-diabetic mice after they had been given IGF-1. Non-diabetic mice recovered more quickly than diabetic mice, suggesting, he said, an insulin resistance state in the diabetic animals.

Next, experimental mice were pre-treated with vanadyl sulfate before exposure to LPS. Recovery after illness of the vanadium-treated mice, diabetic or not, was 50 percent faster than that of the untreated control mice.

"With vanadyl sulfate being like IGF-1, we expected to see resistance in the diabetic animals, but we didn’t see that," Johnson said. "We saw similar improvement. Thus it must have been acting through a different pathway than do IGF-1 or insulin."

Johnson and Freund, also an adjunct professor of animal sciences and a researcher in the immunophysiology and behavior program at Illinois, theorize it may be vanadium’s metal-related shape or its ability to inhibit tyrosine phosphatases, which help to modulate signaling proteins, in the immune system. Freund and colleagues last year documented a connection between serine phosphorylation and anti-inflammatory cytokines.

"Diabetes affects millions of people," Freund said. "It is hard to overcome many of the problems in a nutritionally dependent fashion. This research implies that metals that are trace elements may have more importance than we realize to human health, not only in preventing diseases but also in making you feel better."

It’s possible, Johnson said, that taking vanadyl-sulfate-containing supplements beginning two weeks before possible exposure to gram-negative organisms might help speed recovery from subsequent infection.

Jim Barlow | EurekAlert!
Further information:
http://www.uiuc.edu

More articles from Health and Medicine:

nachricht Spanish scientists create a 3-D bioprinter to print human skin
24.01.2017 | Carlos III University of Madrid

nachricht Tracking movement of immune cells identifies key first steps in inflammatory arthritis
23.01.2017 | Massachusetts General Hospital

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists spin artificial silk from whey protein

X-ray study throws light on key process for production

A Swedish-German team of researchers has cleared up a key process for the artificial production of silk. With the help of the intense X-rays from DESY's...

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Breaking the optical bandwidth record of stable pulsed lasers

24.01.2017 | Physics and Astronomy

Choreographing the microRNA-target dance

24.01.2017 | Life Sciences

Spanish scientists create a 3-D bioprinter to print human skin

24.01.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>