Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Autoimmune overload may damage HIV-infected brain

30.09.2005


White blood cells may be cause of dementia in people with AIDS

Researchers studying the evolution of the human immunodeficiency virus (HIV) in the brain have found that the body’s own defenses may cause HIV-related dementia.

Publishing in the Sept. 2005 issue of the Journal of Virology, the researchers show that HIV in the temporal lobe mutates at a rate 100 times faster than in other parts of the body, triggering white blood cells to continually swarm to attack the infection. The associated overcrowding and inflammation appear to cause the dementia.



Earlier studies had suggested that the build-up of white blood cells could lead to HIV-related dementia, but this is the first study to track the probable mechanism.

The findings could lead to new treatments that target HIV-infected white blood cells, perhaps one day countering the brain wasting that will affect as many as 15 percent of the nearly 40 million people around the world who are infected with the virus.

The study is a collaboration among researchers at the University of California at Irvine, the University of Florida at Gainesville, Gene Johnson, Inc., of St. Augustine, Fla., the University of California at San Francisco (UCSF) and the University of Oxford in the United Kingdom.

One of the critical tools behind the discovery is HIVBase, a genetic data-storage and -analysis tool with which the researchers tracked the rapidly evolving viruses. Gene Johnson developed the tool with the support of an NSF Small Business Innovation Research award.

According to co-author Susanna Lamers of Gene Johnson and UCSF, the results strengthen an earlier hypothesis by Kenneth Williams of Harvard University and William Hickey of Dartmouth Medical School. They had suggested that the continual build-up of white blood cells in the brain could lead to HIV-associated dementia.

"In our work," says Lamers, "we conducted a thorough examination of HIV genetic sequences and were able to prove that the researchers’ concept was a good explanation for both clinical latency--when the body mounts a strong immune defense and the number of viral particles decreases--and the long-term damage associated with HIV infection in the brain. They offered the model, we provided strong evidence that the model is accurate."

Josh Chamot | EurekAlert!
Further information:
http://www.nsf.gov

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Thanks for the memory: NIST takes a deep look at memristors

22.01.2018 | Materials Sciences

Radioactivity from oil and gas wastewater persists in Pennsylvania stream sediments

22.01.2018 | Earth Sciences

Saarland University bioinformaticians compute gene sequences inherited from each parent

22.01.2018 | Life Sciences

VideoLinks Wissenschaft & Forschung
Overview of more VideoLinks >>>