Scientists at the Institute for Medical Research at North Shore-LIJ have made a discovery that refutes two longstanding beliefs about the most common leukemia in the western hemisphere. Due to the relatively slow disease progression of chronic lymphocytic leukemia (CLL), doctors thought it was caused by a gradual accumulation of leukemia cells that could not die. The new findings, published online today in the Journal of Clinical Investigation, prove the exact opposite. The study will appear in the journals March 2005 print issue.
For decades, doctors and scientists believed that CLL was a static disease of long-lived white blood cells (lymphocytes) -- that the leukemia cells were both immortal and born at a slow rate, causing the slow rise in cell count over time. But researchers had been unable to find any problems with the leukemia cells process of cell suicide, called apoptosis, a normal part of the cell life cycle for which all cells are programmed. This was a hint that perhaps the leukemia cells were not immortal. Using a clever study design that required subjects only to drink water and give blood samples, the research team, led by Nicholas Chiorazzi, MD, director and CEO of the Institute for Medical Research, found that the leukemia cells are born at a fast rate and do indeed die. The slow rise in the cell count over time can be attributed to the difference between the birth and death rates of the cells, according to the study.
The scientists also found that there appeared to be a connection between poorer patient outcomes and the faster birth rates of the leukemia cells, regardless of the rate of cell death. "This particular finding may prove helpful in identifying patients who are at risk for worsening disease in advance of showing any clinical signs of deterioration," said Dr. Chiorazzi. He cautioned, however, that additional research is needed to establish its potential in guiding prognostic and treatment decisions. The study was small, examining 19 CLL patients.
Christina Verni | EurekAlert!
Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania
The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration
"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...
Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.
Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
16.01.2017 | Trade Fair News
16.01.2017 | Automotive Engineering
16.01.2017 | Life Sciences