Treating chest infections in young cystic fibrosis patients with an antibiotic once instead of three times daily is as effective and less toxic, conclude the results of a randomised trial published in this week’s issue of THE LANCET.
Aminoglycoside antibiotics are widely used for the management of patients who have cystic fibrosis and chronic chest infection with a bacterium called Pseudomonas aerginosa. Currently patients are given aminoglycosides three times daily. The drugs can cause damage to kidney function and hearing loss.
Alan Smyth (University of Nottingham, UK) and colleagues recruited 219 cystic fibrosis patients (125 children and 94 adults) between 1999 and 2003 in the UK. The patients were randomly assigned to receive an aminoglycoside called tobramycin intravenously once or three times daily for 14 days. The researchers measured changes in lung function and found that the two treatments had a similar effect. However in children, the once daily treatment caused fewer kidney related side effects.
Udani Samarasekera | alfa
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Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
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For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.
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