A new study by scientists at Fred Hutchinson Cancer Research Center provides insight into why some men develop aggressive prostate cancer that becomes resistant to hormone-withdrawal therapy, a common form of treatment.
Researchers found that certain mutations in a protein called the androgen receptor cause advanced and invasive prostate cancer when put into otherwise healthy mice. The androgen receptors normal function is to control growth of the prostate gland in response to cues from male hormones called androgens, which have long been thought to stimulate prostate tumors.
Because similarly defective androgen receptors have been found in prostate-cancer patients whose disease is resistant to hormone withdrawal, the finding sheds light on why most men with advanced prostate cancer treated with hormone-withdrawal therapy fail to be cured. The work opens the door to discovery of new, more effective therapies, according to Norman Greenberg, Ph.D., a member of Fred Hutchinsons Clinical Research Division.
Dean Forbes | EurekAlert!
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