The best method for preventing HIV patients from developing drug resistance is a careful, dedicated adherence to their prescribed drug regimen, according to a long-term, large-scale study presented today in New York City at the American Medical Association Media Briefing, HIV/AIDS, The Drug Resistance Epidemic. Other key predictors of resistance include measures of how much virus was present in a persons bloodstream at the start of therapy and how much their immune status was compromised.
"We have a lot of studies showing that triple therapy works, as well as a lot of good information on the problem of resistance developing in triple antiretroviral therapy," said Richard Harrigan, Ph.D., director of the British Columbia Centre for Excellence in HIV Research Labs at St. Pauls Hospital in Vancouver and lead author of the paper. "The problem with past studies is that they were limited to people in clinical trials and as people drop out they are lost to the study. In this study, we followed people beginning initial triple therapy for 30 months and were able to really get a sense of how the therapy works outside of clinical trials."
Triple therapy for HIV/AIDS is designed to hit the virus with three or more antiretroviral drugs from two or more different classes at once in order to reduce the viral load (amount of virus circulating in the blood) so drastically that the virus is not replicating enough to mutate and become resistant to the drugs designed to fight it, Dr. Harrigan explained.
Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences
What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy