Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers discover clues to cirrhosis

20.12.2004


Researchers at the University of Essex have found new biochemical indicators of cirrhosis in blood plasma which could help detect the disease in its early stages.



The findings of the project, which was led by Professor Paul Thornalley, of the Disease Mechanisms and Therapeutics Research Group in the Department of Biological Sciences, suggest these markers could be used to assess damage to the liver and the likelihood of developing cirrhosis which could have a significant effect on choosing appropriate therapy.

Cirrhosis is scarring of the liver involving the formation of fibrous (scar) tissue. There is severe impairment of liver function in the advanced state but recent advances in drug development have led to the view that fibrosis may in the future become reversible.


In the UK, cirrhosis is mainly caused by chronic alcohol abuse and hepatitis C infection. Ten to fifteen per cent of chronic alcoholic subjects develop alcoholic cirrhosis, of whom 75 per cent will eventually die as a consequence of liver disease. Inflammation in the liver with uncontrolled damage to lipids is thought to be involved. The new marker discovered is the debris of proteins damaged in the liver during the development of the disease by reaction with glyoxal which may be lipid or alcohol-derived.

Professor Thornalley, who collaborated with research teams in Düsseldorf and Würzburg, Germany, explained: ’Further time course studies will be required to assess the reliability of these markers in assessment of the development of cirrhosis. Since protein damage is an early hallmark of cirrhosis, it is likely that debris from this damage, leaking into the blood, will provide a novel biochemical test for early liver damage.’

The research project has been supported by the Wellcome Trust (UK) and the findings have been published online in the Journal of Hepatology (Elsevier).

Kate Cleveland | alfa
Further information:
http://www.essex.ac.uk/news

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>