Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Drug to treat ADHD has similar effect on children with reading disorders

14.12.2004


The drug methylphenidate (brand name Ritalin) increased activity in brains of children with attention-deficit/hyperactivity disorder (ADHD) as well as those with a reading disorder, researchers at Yale report in the American Journal of Psychiatry.
"During a test of divided attention, Ritalin increased activation in the basal ganglia, a structure of the brain involved in cognition and behavior," said first author Keith Shafritz, former graduate student in the interdepartmental Neuroscience Program at Yale and now a research associate at Duke University Medical Center. "We saw this activation in children with ADHD and those with reading disorder."
The study used functional magnetic resonance imaging (fMRI) to analyze the effect of the drug on brain function. Researchers found that adolescents with ADHD or reading disorder who were on placebo (not medicated) had less activation of the basal ganglia than a group of healthy participants. When the same participants received Ritalin, the drug normalized the activation, which relates to the amount of blood flow to a specific brain region in response to a cognitive task.

ADHD is characterized by inattention, but previous neuroimaging studies have examined the brain dysfunction associated with impulsivity. "This is one of few studies that used a test for attention rather than a cognitive test for impulsivity," said Shafritz. "It is also the first study, using fMRI to find that the attention circuitry in the brain is directly affected by ADHD."



The 27 study participants, ages 14 to 18 with either ADHD or reading disorder, were randomly assigned to receive Ritalin first or placebo first and didn’t know to which group they were assigned. While in the MRI, the participants were given auditory or visual performance tasks to decide whether they saw or heard a real English word or a nonsense word. Their results were compared to a group of 14 healthy adolescents who were not given Ritalin.

Although Ritalin did not affect performance, it altered the areas of the brain that were active during the simple performance of tasks. These results suggest that both ADHD and reading disorder are associated with dysfunction in the brain’s attentional circuitry and that methylphenidate normalizes activation within this neural system.

Karen N. Peart | EurekAlert!
Further information:
http://www.yale.edu

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

New pop-up strategy inspired by cuts, not folds

27.02.2017 | Materials Sciences

Sandia uses confined nanoparticles to improve hydrogen storage materials performance

27.02.2017 | Interdisciplinary Research

Decoding the genome's cryptic language

27.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>