Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Nuclear imaging offers possibility for early detection of patients with coronary heart disease

16.11.2004


Nuclear imaging will play an increasing role in both the detection of atherosclerosis (coronary heart disease) and, more specifically, the composition of plaque build up that can block the flow of blood through an artery, according to journal reports published by the Society of Nuclear Medicine.



A trio of articles, "Evaluation of 18F-FDG Uptake and Arterial Wall Calcifications Using 18F-FDG PET/CT," "Molecular and Metabolic Imaging of Atherosclerosis" and "Noninvasive Imaging of Atherosclerosis: The Biology Behind the Pictures," appears in the November 2004 issue of "The Journal of Nuclear Medicine."

Heart disease, in the news recently because of former President Bill Clinton’s quadruple coronary artery bypass surgery, is one of the leading causes of death worldwide. According to SNM members Simona Ben-Haim, M.D., and Ora Israel, M.D., "combined positron emission tomography and computed tomography may be helpful in the detection of early abnormalities in the arterial wall." They said, "These abnormalities may be the cause of future severe cardiovascular events … the PET/CT scan may be potentially useful in early detection of disease, prevention, monitoring response to therapy and prognosis." This preliminary study, which took more than three years, could establish a role for nuclear medicine as a noninvasive imaging tool for atherosclerosis, providing both functional and anatomical information. The results of the study, one of the first of its kind, are detailed in "Evaluation of 18F-FDG Uptake and Arterial Wall Calcifications Using 18F-FDG PET/CT." While the results are exciting, the two authors said that more research is needed "to confirm our results and lead to the understanding of their clinical significance."


While Clinton’s angiogram showed he had blockage in some coronary arteries caused by fatty plaque accumulated over the years, the authors of "Molecular and Metabolic Imaging of Atherosclerosis" pointed out that, "recent advances in understanding of the pathobiology of atherosclerosis have highlighted the inadequacies" of imaging the disease with X-ray angiography. John R. Davies, B.Sc.; James H. Rudd, Ph.D.; and Peter L. Weissberg, M.D., stated the need for better imaging approaches and outlined the biology of atherosclerosis, reviewing both invasive and noninvasive (such as 18F-FDG PET) imaging techniques available, especially those that detect metabolic or inflammatory changes within detected plaque. Advances in understanding cell biology show a need for imaging techniques that can provide information about plaque composition and drive the development of more informative imaging techniques, they say. "Nuclear imaging has the potential to provide invaluable information on the cellular, metabolic and molecular composition of the plaque," note the authors.

In the journal’s invited perspective, "Noninvasive Imaging of Atherosclerosis: The Biology Behind the Pictures," Weissberg writes, "It has taken the best part of 50 years for us to learn that angiography tells us very little about atherosclerotic plaques." He added, "It is crucial that we learn more quickly what newer imaging techniques are telling us."

Maryann Verrillo | EurekAlert!
Further information:
http://www.snm.org

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>