Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Nuclear imaging offers possibility for early detection of patients with coronary heart disease

16.11.2004


Nuclear imaging will play an increasing role in both the detection of atherosclerosis (coronary heart disease) and, more specifically, the composition of plaque build up that can block the flow of blood through an artery, according to journal reports published by the Society of Nuclear Medicine.



A trio of articles, "Evaluation of 18F-FDG Uptake and Arterial Wall Calcifications Using 18F-FDG PET/CT," "Molecular and Metabolic Imaging of Atherosclerosis" and "Noninvasive Imaging of Atherosclerosis: The Biology Behind the Pictures," appears in the November 2004 issue of "The Journal of Nuclear Medicine."

Heart disease, in the news recently because of former President Bill Clinton’s quadruple coronary artery bypass surgery, is one of the leading causes of death worldwide. According to SNM members Simona Ben-Haim, M.D., and Ora Israel, M.D., "combined positron emission tomography and computed tomography may be helpful in the detection of early abnormalities in the arterial wall." They said, "These abnormalities may be the cause of future severe cardiovascular events … the PET/CT scan may be potentially useful in early detection of disease, prevention, monitoring response to therapy and prognosis." This preliminary study, which took more than three years, could establish a role for nuclear medicine as a noninvasive imaging tool for atherosclerosis, providing both functional and anatomical information. The results of the study, one of the first of its kind, are detailed in "Evaluation of 18F-FDG Uptake and Arterial Wall Calcifications Using 18F-FDG PET/CT." While the results are exciting, the two authors said that more research is needed "to confirm our results and lead to the understanding of their clinical significance."


While Clinton’s angiogram showed he had blockage in some coronary arteries caused by fatty plaque accumulated over the years, the authors of "Molecular and Metabolic Imaging of Atherosclerosis" pointed out that, "recent advances in understanding of the pathobiology of atherosclerosis have highlighted the inadequacies" of imaging the disease with X-ray angiography. John R. Davies, B.Sc.; James H. Rudd, Ph.D.; and Peter L. Weissberg, M.D., stated the need for better imaging approaches and outlined the biology of atherosclerosis, reviewing both invasive and noninvasive (such as 18F-FDG PET) imaging techniques available, especially those that detect metabolic or inflammatory changes within detected plaque. Advances in understanding cell biology show a need for imaging techniques that can provide information about plaque composition and drive the development of more informative imaging techniques, they say. "Nuclear imaging has the potential to provide invaluable information on the cellular, metabolic and molecular composition of the plaque," note the authors.

In the journal’s invited perspective, "Noninvasive Imaging of Atherosclerosis: The Biology Behind the Pictures," Weissberg writes, "It has taken the best part of 50 years for us to learn that angiography tells us very little about atherosclerotic plaques." He added, "It is crucial that we learn more quickly what newer imaging techniques are telling us."

Maryann Verrillo | EurekAlert!
Further information:
http://www.snm.org

More articles from Health and Medicine:

nachricht 'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS

nachricht New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

'Lipid asymmetry' plays key role in activating immune cells

20.02.2018 | Life Sciences

MRI technique differentiates benign breast lesions from malignancies

20.02.2018 | Medical Engineering

Major discovery in controlling quantum states of single atoms

20.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>