Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Smoking triggers early onset of pancreatic cancer

08.11.2004


A new study finds tobacco may act as an environmental trigger for patients with an inherited genetic predisposition to pancreatic cancer. The authors of the report say the findings underscore the importance of strongly counseling patients with a family history of pancreatic cancer to avoid smoking. The study will be published in the December 15, 2004 issue of CANCER, a peer-reviewed journal of the American Cancer Society. A free abstract of this study will be available via the CANCER News Room upon online publication.



Pancreatic cancer is rare and poorly studied. What is known is that pancreatic cancer is aggressive, with a five-year survival rate of only 4 percent. A small percentage of patients with pancreatic cancer have first-degree relatives with pancreatic cancer. Smoking has been identified as the single most important risk factor in familial pancreatic cancer. Despite genetic characterization of other hereditary cancers, the genetic component of pancreatic cancer remains a mystery. With such little known about what is now called familial pancreatic adenocarcinoma (FPAC), researchers led by Ted A. James, M.D. of the Roswell Park Cancer Institute in Buffalo, New York investigated the clinical course and outcome of FPAC compared to sporadic pancreatic cancer.

Retrospective review of 826 patients with pancreatic cancer found 30 had the familial form (3.6 percent). Earlier age at diagnosis and a smoking history were marked features among the familial group. The mean age of diagnosis was younger in the hereditary cohort than among those with the sporadic form (57.1 years old versus 61 years old), and more FPAC patients were diagnosed before the age of 50 (36.7 percent versus 18.3 percent). Moreover, patients with FPAC were more likely to smoke than those who had sporadic pancreatic cancer (87 percent versus 66 percent).


The authors of the report conclude, "Patients with a family history of pancreatic cancer must be strongly counseled against smoking, and smokers with a family history of pancreatic cancer should be informed of their increased risk and offered enrollment into a smoking cessation program."

Amy Molnar | EurekAlert!
Further information:
http://www.interscience.wiley.com/cancer-newsroom
http://www.wiley.com

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

Im Focus: Repairing defects in fiber-reinforced plastics more efficiently

Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.

Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Multiregional brain on a chip

16.01.2017 | Power and Electrical Engineering

New technology enables 5-D imaging in live animals, humans

16.01.2017 | Information Technology

Researchers develop environmentally friendly soy air filter

16.01.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>