A new study finds tobacco may act as an environmental trigger for patients with an inherited genetic predisposition to pancreatic cancer. The authors of the report say the findings underscore the importance of strongly counseling patients with a family history of pancreatic cancer to avoid smoking. The study will be published in the December 15, 2004 issue of CANCER, a peer-reviewed journal of the American Cancer Society. A free abstract of this study will be available via the CANCER News Room upon online publication.
Pancreatic cancer is rare and poorly studied. What is known is that pancreatic cancer is aggressive, with a five-year survival rate of only 4 percent. A small percentage of patients with pancreatic cancer have first-degree relatives with pancreatic cancer. Smoking has been identified as the single most important risk factor in familial pancreatic cancer. Despite genetic characterization of other hereditary cancers, the genetic component of pancreatic cancer remains a mystery. With such little known about what is now called familial pancreatic adenocarcinoma (FPAC), researchers led by Ted A. James, M.D. of the Roswell Park Cancer Institute in Buffalo, New York investigated the clinical course and outcome of FPAC compared to sporadic pancreatic cancer.
Retrospective review of 826 patients with pancreatic cancer found 30 had the familial form (3.6 percent). Earlier age at diagnosis and a smoking history were marked features among the familial group. The mean age of diagnosis was younger in the hereditary cohort than among those with the sporadic form (57.1 years old versus 61 years old), and more FPAC patients were diagnosed before the age of 50 (36.7 percent versus 18.3 percent). Moreover, patients with FPAC were more likely to smoke than those who had sporadic pancreatic cancer (87 percent versus 66 percent).
Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
20.10.2017 | Interdisciplinary Research
20.10.2017 | Materials Sciences
20.10.2017 | Earth Sciences