Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Therapeutic Target for Potential Rheumatic Disease Treatment

11.10.2004


Medical investigators at the Hospital for Special Surgery have identified an important new signaling pathway they believe could be a valuable target for scientists to aim at with future drug therapies that might one day reverse diseases such as systemic lupus erythematosus, according to a recent article published in “Nature Immunology.”



The chemical pathway involves the body’s responses to potent substances called cytokines which have dramatic influence on the progression, or reversal, of diseases such as rheumatoid arthritis and lupus.

Doctors have long known that cytokines can regulate diseases such as lupus, but it is now becoming appreciated that lupus can also make cytokines fail to work properly. What is not fully understood is just how the cytokines become “switched on” to cause damage. Understanding the molecular chemistry that turns on the switch becomes central to stemming disease.


The HHS in vitro and animal study work focused on the key role of interferon chemicals produced in the body as they impact cytokines production and influence inflammation. One particular kind of interferon (IFN), IFN-alpha, was believed to play a key role in lupus and is a therapeutic target for this disease. The investigators found that inflammation, as it occurs in lupus patients, changed cellular responses to IFN-alpha and made cellular response become more inflammatory and toxic.

This work supports a concept that is emerging from the laboratory of, Lionel B. Ivashkiv, M.D., lead investigator in the study at HSS published Oct 3, 2004 in “Nature Immunology.” The paper is titled “Amplification of IFN-alpha induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors.”

Specifically Dr. Ivashkiv believes that cytokine signaling is reprogrammed in patients with rheumatic diseases. This reprogramming amplifies the toxic aspects of cytokines, while compromising the effectiveness of “good cytokines” that patients produce in their bodies in an attempt to heal themselves. “We found that if we inject these IFNs in a normal mouse, there was no effect but if we injected the IFN-alpha in a mouse with lupus, we saw evidence of an influx of cells and the start of inflammation at the site where it was injected,” said Dr. Ivashkiv.

“People with rheumatic diseases like lupus and arthritis have cytokine response problems that prevent these chemicals from working properly and doing what they are supposed to do to heal the body. If we can identify and influence the chemicals that result in this and prevent it from happening, we can prevent the cycle of inflammatory response that damages these patients instead of helping them,” said Dr. Ivashkiv.

In lupus, the immune system attacks the body’s own cells and tissue, especially the skin, joints, blood, heart, lungs and kidneys. It affects 1-1.5 million Americans and is a leading cause of kidney disease, stroke and cardiovascular disease in young women.

| newswise
Further information:
http://www.hss.edu
http://www.nature.com

More articles from Health and Medicine:

nachricht Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center

nachricht Overdosing on Calcium
19.06.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Creating a new composite fuel for new-generation fast reactors

20.06.2018 | Materials Sciences

Game-changing finding pushes 3D-printing to the molecular limit

20.06.2018 | Materials Sciences

Could this material enable autonomous vehicles to come to market sooner?

20.06.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>