Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Breast density, rapid tumor growth contribute to mammogram failure in women in their forties

06.10.2004


Lower sensitivity of mammography in women aged 40 to 49 years compared with older women can be largely explained by greater breast density and rapid tumor growth in the younger women, according to a new study in the October 6 issue of the Journal of the National Cancer Institute.



Because mammography is imperfect for women in their 40s, there has been controversy over whether and how often these women should be screened. Mammographic sensitivity--that is, the percentage of cancers detected by a mammogram--is lower in this group of women than in older women. Several factors have been suggested as contributing to the lower mammographic sensitivity, including higher breast density, faster tumor growth rate, and differences in the distribution of breast cancer risk factors.

To analyze the relative contributions of these factors to differences in mammographic sensitivity between younger and older women, Diana S. M. Buist, Ph.D., of Group Health Cooperative in Seattle, and colleagues studied 576 women (73 aged 40 to 49 years and 503 aged 50 years and older) who were diagnosed with invasive breast cancer between 1988 and 1993. They looked at associations between potential explanatory factors and the odds of having an interval cancer (cancer diagnosed within 12 or 24 months after a negative screening mammogram and before a subsequent mammogram).


Interval cancers occurred in 27.7% of the younger women and 13.9% of the older women within 12 months of a screening mammogram and in 52.1% of younger women and 24.7% of older women within 24 months. Greater breast density--which has been shown to reduce mammographic quality--explained 67.6% of the decreased mammographic sensitivity in younger women at 12 months. Rapid tumor growth explained 30.6% and greater breast density explained 37.6% of the decreased sensitivity in younger women at 24 months. The authors suggest that screening younger women at yearly intervals may reduce the adverse impact on mammographic sensitivity of rapid tumor growth that occurs in young women.

"There are 21.7 million women in the United States aged 40–49 years, approximately 50% of whom have dense breasts," the authors write. "It may be that digital mammography, computer-aided detection, magnetic resonance imaging, and/or ultrasound can improve cancer detection in women with dense breast tissue."

Sarah L. Zielinski | EurekAlert!
Further information:
http://www.oupjournals.org

More articles from Health and Medicine:

nachricht A 'half-hearted' solution to one-sided heart failure
24.11.2017 | Boston Children's Hospital

nachricht New study points the way to therapy for rare cancer that targets the young
22.11.2017 | Rockefeller University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New proton record: Researchers measure magnetic moment with greatest possible precision

High-precision measurement of the g-factor eleven times more precise than before / Results indicate a strong similarity between protons and antiprotons

The magnetic moment of an individual proton is inconceivably small, but can still be quantified. The basis for undertaking this measurement was laid over ten...

Im Focus: Frictional Heat Powers Hydrothermal Activity on Enceladus

Computer simulation shows how the icy moon heats water in a porous rock core

Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

IceCube experiment finds Earth can block high-energy particles from nuclear reactions

24.11.2017 | Physics and Astronomy

A 'half-hearted' solution to one-sided heart failure

24.11.2017 | Health and Medicine

Heidelberg Researchers Study Unique Underwater Stalactites

24.11.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>