Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Breast density, rapid tumor growth contribute to mammogram failure in women in their forties

06.10.2004


Lower sensitivity of mammography in women aged 40 to 49 years compared with older women can be largely explained by greater breast density and rapid tumor growth in the younger women, according to a new study in the October 6 issue of the Journal of the National Cancer Institute.



Because mammography is imperfect for women in their 40s, there has been controversy over whether and how often these women should be screened. Mammographic sensitivity--that is, the percentage of cancers detected by a mammogram--is lower in this group of women than in older women. Several factors have been suggested as contributing to the lower mammographic sensitivity, including higher breast density, faster tumor growth rate, and differences in the distribution of breast cancer risk factors.

To analyze the relative contributions of these factors to differences in mammographic sensitivity between younger and older women, Diana S. M. Buist, Ph.D., of Group Health Cooperative in Seattle, and colleagues studied 576 women (73 aged 40 to 49 years and 503 aged 50 years and older) who were diagnosed with invasive breast cancer between 1988 and 1993. They looked at associations between potential explanatory factors and the odds of having an interval cancer (cancer diagnosed within 12 or 24 months after a negative screening mammogram and before a subsequent mammogram).


Interval cancers occurred in 27.7% of the younger women and 13.9% of the older women within 12 months of a screening mammogram and in 52.1% of younger women and 24.7% of older women within 24 months. Greater breast density--which has been shown to reduce mammographic quality--explained 67.6% of the decreased mammographic sensitivity in younger women at 12 months. Rapid tumor growth explained 30.6% and greater breast density explained 37.6% of the decreased sensitivity in younger women at 24 months. The authors suggest that screening younger women at yearly intervals may reduce the adverse impact on mammographic sensitivity of rapid tumor growth that occurs in young women.

"There are 21.7 million women in the United States aged 40–49 years, approximately 50% of whom have dense breasts," the authors write. "It may be that digital mammography, computer-aided detection, magnetic resonance imaging, and/or ultrasound can improve cancer detection in women with dense breast tissue."

Sarah L. Zielinski | EurekAlert!
Further information:
http://www.oupjournals.org

More articles from Health and Medicine:

nachricht GLUT5 fluorescent probe fingerprints cancer cells
20.04.2018 | Michigan Technological University

nachricht Scientists re-create brain neurons to study obesity and personalize treatment
20.04.2018 | Cedars-Sinai Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Magnetic nano-imaging on a table top

20.04.2018 | Physics and Astronomy

Start of work for the world's largest electric truck

20.04.2018 | Interdisciplinary Research

Atoms may hum a tune from grand cosmic symphony

20.04.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>