Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Breast density, rapid tumor growth contribute to mammogram failure in women in their forties


Lower sensitivity of mammography in women aged 40 to 49 years compared with older women can be largely explained by greater breast density and rapid tumor growth in the younger women, according to a new study in the October 6 issue of the Journal of the National Cancer Institute.

Because mammography is imperfect for women in their 40s, there has been controversy over whether and how often these women should be screened. Mammographic sensitivity--that is, the percentage of cancers detected by a mammogram--is lower in this group of women than in older women. Several factors have been suggested as contributing to the lower mammographic sensitivity, including higher breast density, faster tumor growth rate, and differences in the distribution of breast cancer risk factors.

To analyze the relative contributions of these factors to differences in mammographic sensitivity between younger and older women, Diana S. M. Buist, Ph.D., of Group Health Cooperative in Seattle, and colleagues studied 576 women (73 aged 40 to 49 years and 503 aged 50 years and older) who were diagnosed with invasive breast cancer between 1988 and 1993. They looked at associations between potential explanatory factors and the odds of having an interval cancer (cancer diagnosed within 12 or 24 months after a negative screening mammogram and before a subsequent mammogram).

Interval cancers occurred in 27.7% of the younger women and 13.9% of the older women within 12 months of a screening mammogram and in 52.1% of younger women and 24.7% of older women within 24 months. Greater breast density--which has been shown to reduce mammographic quality--explained 67.6% of the decreased mammographic sensitivity in younger women at 12 months. Rapid tumor growth explained 30.6% and greater breast density explained 37.6% of the decreased sensitivity in younger women at 24 months. The authors suggest that screening younger women at yearly intervals may reduce the adverse impact on mammographic sensitivity of rapid tumor growth that occurs in young women.

"There are 21.7 million women in the United States aged 40–49 years, approximately 50% of whom have dense breasts," the authors write. "It may be that digital mammography, computer-aided detection, magnetic resonance imaging, and/or ultrasound can improve cancer detection in women with dense breast tissue."

Sarah L. Zielinski | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>