Transplant surgeons at Thomas Jefferson University Hospital in Philadelphia have found that a new combination of drugs results in fewer incidences of rejection in liver transplant patients than do current treatments.
Surgeons, led by Ignazio Marino, M.D., director of the Division of Liver Transplantation and Hepato-biliary Surgery at Thomas Jefferson University Hospital, analyzed the results of 50 liver transplant procedures they performed between 2000 and 2002. To try to prevent or lessen the severity of rejection, Dr. Marinos group used a monoclonal antibody, basiliximab, as part of a group of drugs that included tacrolimus, a standard anti-rejection agent, and low doses of steroids. Basiliximab, which ties up an important immune system cell (IL-2) receptor, has been used for kidney transplantation.
The group found a much lower incidence of liver rejection.
Steve Benowitz | EurekAlert!
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