Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Jefferson liver transplant surgeons show less rejection, better survival with drug regimen

23.09.2004


Transplant surgeons at Thomas Jefferson University Hospital in Philadelphia have found that a new combination of drugs results in fewer incidences of rejection in liver transplant patients than do current treatments.



Surgeons, led by Ignazio Marino, M.D., director of the Division of Liver Transplantation and Hepato-biliary Surgery at Thomas Jefferson University Hospital, analyzed the results of 50 liver transplant procedures they performed between 2000 and 2002. To try to prevent or lessen the severity of rejection, Dr. Marino’s group used a monoclonal antibody, basiliximab, as part of a group of drugs that included tacrolimus, a standard anti-rejection agent, and low doses of steroids. Basiliximab, which ties up an important immune system cell (IL-2) receptor, has been used for kidney transplantation.

The group found a much lower incidence of liver rejection.


"When we added basiliximab, the rate of rejection dropped dramatically to 12 percent," says Dr. Marino, who is also professor of surgery at Jefferson Medical College of Thomas Jefferson University and the interim director of the Division of Transplantation at Thomas Jefferson University Hospital. He notes that the rate, which is after one year, is comparable to a French study that showed that 38 percent of patients had a rejection episode in the first year. Another trial conducted by the University of Pittsburgh had a 45 percent rejection rate after one year. "The big advantage [of this combination of drugs] is that the incidence of rejection is significantly decreased," he says. "These results could change the standard of care for liver transplant recipients."

The study findings appear Sept. 27, 2004 in the journal Transplantation. The results show that the drugs may have helped improve survival as well. Of the 50 patients who received transplants, 88 percent were alive three years later (The actuarial survival rate at three years was 88 percent.). According to the Transplant Liver Registry of the United Network for Organ Sharing, approximately 78 percent of those who receive liver transplants live for at least three years.

Dr. Marino notes that in the past 15 months of using this combination of drugs for liver transplants at Jefferson, the one-year patient survival is 100 percent.

According to Dr. Marino, in the 1990s at the University of Pittsburgh, surgeons developed a tacrolimus-based drug combination that changed the face of liver transplantation. Its use greatly decreased the reliance on steroids, which can produce nasty side effects, but high doses of the drug caused neurotoxicity and kidney toxicity. In the last decade, surgeons began using antibodies that were given to the patient initially before surgery in an attempt to reduce side effects from high doses of tacrolimus.

Tacrolimus is a drug that suppresses the immune system by inhibiting an enzyme (calcineurin) crucial for T-cell proliferation, which is important in the immune process. The Jefferson surgeons’ trial marks the first time anyone had evaluated the effectiveness and safety of basiliximab and tacrolimus to suppress the immune system to prevent the body’s rejection of a liver. "We think we have much less toxicity in the short term because we use less tacrolimus," he says. They also expect less toxicity in the long term as well because they used fewer steroids. As a result, he says, they expect fewer complications associated with long-term steroid use, which includes hypertension, osteoporosis and diabetes.

Dr. Marino has also discovered that basiliximab may affect hepatitis C virus (HCV) recurrence. "We also suspect that the recurrence of HCV is lower, though we don’t have enough data to confirm this," he says. Typically, immunosuppressed liver transplant patients experience high rates of HCV recurrences, Dr. Marino notes, because the virus has fewer restrictions on its growth. Perhaps, he says, the anti-IL2 monoclonal has some mechanism affecting the replication of the HCV.

"If this observation can be confirmed, it’s important news because 60 percent of the patients we transplant are diagnosed with HCV. This would mean an immunosuppression that can delay the recurrence of HCV on top of having fewer episodes of rejection and toxicity than before."

While Dr. Marino says that he would like to continue to investigate whether these drugs indeed reduce the recurrence of HCV, he has another clinical trial in mind. "We would like to begin a new study with no steroids – just two doses of this new drug at the time of the liver transplant and then tacrolimus for life," he says. "We think in the long term, we need to shift the paradigm of immune suppression," he says. "We may someday be able to wean patients away from immune suppression."

Steve Benowitz | EurekAlert!
Further information:
http://www.jefferson.edu

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

On the way to developing a new active ingredient against chronic infections

21.08.2017 | Life Sciences

Smart Computers

21.08.2017 | Information Technology

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>