Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New technique for thyroid cancer therapy eliminates many side effects

20.09.2004


Differentiated thyroid cancer, the most common form of thyroid cancer, is one of the success stories in the war on cancer. Since the advent of radioiodine therapy, it has been considered one of the most curable cancers. On the downside, current treatment involves taking patients off their thyroid medication. This can lead to serious side effects including symptoms of hypothyroidism, an unbalanced metabolic state that can induce fatigue, depression, and other unpleasant conditions.



Bart de Keizer, MD, and a team from the University Medical Center in Utrecht, The Netherlands, and Ghent University Hospital, Belgium, reported in the September issue of The Journal of Nuclear Medicine, on a new technique that allows patients to maintain their normal course of thyroid medication prior to and during radioiodine therapy. The new technique avoids the problems of hypothyroidism, and levels of radiation in the blood and bone marrow remain well below the accepted safety thresholds during therapy.

Currently, thyroid cancer patients who have had their thyroid removed are treated with radioactive iodine, which effectively zeros in on and kills any remaining cancerous thyroid cells. But prior to radioiodine treatment, the patient must be taken off thyroid hormone replacement medication for up to 6 weeks. The withdrawal of thyroid medication signals the body to produce thyroid stimulating hormone (THS). TSH causes any remaining or metastasized thyroid cells to quickly absorb the radioactive iodine when it is administered, in effect forcing the cancerous cells to absorb lethal radioactive molecules that are largely ignored by other cells in the body.


By using a genetically engineered version of the natural hormone (recombinant human thyroid stimulating hormone [rhTSH]) instead of thyroid medication withdrawal to stimulate the cancerous cells to quickly take up the radioactive iodine, the research team in The Netherlands and Belgium found that the problems of hypothyroidism can be avoided. This new technique may also increase the safety of radioiodine treatment and may allow a higher, more effective dose of radioiodine to be used when needed. That’s because when the body is not in a state of hypothyroidism, it can more efficiently process and excrete any radioiodine that hasn’t been absorbed.

The study, which involved 14 patients and 17 treatments, showed that treatment with rhTSH was well tolerated. None of the patients showed blood toxicity, and no bone marrow-related side effects were noted. Blood and bone marrow are the tissues most sensitive to radiation. As expected, none of the patients showed symptoms of hypothyroidism during or following treatment.

According to Dr. de Keizer, "Using rhTSH before administering radioiodine treatments resulted in no clinically relevant side effects. Therefore, although further testing needs to be done, our findings imply this treatment should improve efficacy while preserving safety and tolerability of treatment."

Ann Coleman | EurekAlert!
Further information:
http://www.snm.org
http://jnm.snmjournals.org

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Thanks for the memory: NIST takes a deep look at memristors

22.01.2018 | Materials Sciences

Radioactivity from oil and gas wastewater persists in Pennsylvania stream sediments

22.01.2018 | Earth Sciences

Saarland University bioinformaticians compute gene sequences inherited from each parent

22.01.2018 | Life Sciences

VideoLinks Wissenschaft & Forschung
Overview of more VideoLinks >>>