Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Some HIV patients treated during early infection test negative

12.07.2004


UCSF researchers have found that some HIV patients treated with antiretroviral therapy early after infection do test negative, at some point, for the virus. Study findings showed this result in six of 87 patients.



"First, these patients are not cured. When these patients went off therapy, HIV virus levels rebounded. These results do show that with effective early treatment that reduces the virus to very low levels, the immune system may have less antibody response to HIV," said the study’s lead author, C. Bradley Hare, MD, UCSF assistant clinical professor of medicine at UCSF’s Positive Health Program (PHP) at San Francisco General Hospital Medical Center.

The 87 patients who qualified for the study must have started antiretroviral therapy within 28 days of entry into the study. They also must have achieved and maintained for at least 24 weeks a level of virus in their blood below the level of detectability using very sensitive viral load testing. At some point during their follow-up, six patients tested negative for the HIV virus using standard HIV antibody tests.


Hare presented the study at the XV International AIDS Conference in Bangkok, Thailand on July 12.

Study participants were selected from the Options Project Cohort. Patients in this cohort enter the study in either primary or early infection -- meaning no patient had been infected with the HIV virus for more than six months.

The six patients who tested negative for the HIV virus were tested using standard second- and third-generation Enzyme Immunoassays, which are the most commonly used tests to screen for HIV infection, and Western Blot tests, which are the most commonly used tests for confirming HIV infection.

Co-authors for the study are Brandee Pappalardo, PhD, MPH, staff scientist at the Blood Systems Research Institute, San Francisco; Bruce Phelps, Chiron Corporation, Emeryville, CA; Steven S. Alexander, Ortho Clinical Diagnostics, Raritan, NJ; Clarissa Ramstead, nurse practitioner at the UCSF PHP; Jay A. Levy, UCSF professor of medicine and director of the Laboratory for Tumor and AIDS Virus Research; Frederick M. Hecht, MD, associate clinical professor of medicine at the UCSF PHP; Michael P. Busch, MD, PhD, vice president, Research & Scientific Services, Blood Centers of the Pacific, and UCSF adjunct professor of laboratory medicine.

Funding for this research was provided by grants from the National Institutes of Health and the Centers for Disease Control.

The Positive Health Program is a component of the UCSF AIDS Research Institute (ARI). UCSF ARI houses hundreds of scientists and dozens of programs throughout UCSF and affiliated labs and institutions, making ARI one of the largest AIDS research entities in the world.

Jeff Sheehy | EurekAlert!
Further information:
http://www.ucsf.edu

More articles from Health and Medicine:

nachricht Spanish scientists create a 3-D bioprinter to print human skin
24.01.2017 | Carlos III University of Madrid

nachricht Tracking movement of immune cells identifies key first steps in inflammatory arthritis
23.01.2017 | Massachusetts General Hospital

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists spin artificial silk from whey protein

X-ray study throws light on key process for production

A Swedish-German team of researchers has cleared up a key process for the artificial production of silk. With the help of the intense X-rays from DESY's...

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Breaking the optical bandwidth record of stable pulsed lasers

24.01.2017 | Physics and Astronomy

Choreographing the microRNA-target dance

24.01.2017 | Life Sciences

Spanish scientists create a 3-D bioprinter to print human skin

24.01.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>