Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Some HIV patients treated during early infection test negative

12.07.2004


UCSF researchers have found that some HIV patients treated with antiretroviral therapy early after infection do test negative, at some point, for the virus. Study findings showed this result in six of 87 patients.



"First, these patients are not cured. When these patients went off therapy, HIV virus levels rebounded. These results do show that with effective early treatment that reduces the virus to very low levels, the immune system may have less antibody response to HIV," said the study’s lead author, C. Bradley Hare, MD, UCSF assistant clinical professor of medicine at UCSF’s Positive Health Program (PHP) at San Francisco General Hospital Medical Center.

The 87 patients who qualified for the study must have started antiretroviral therapy within 28 days of entry into the study. They also must have achieved and maintained for at least 24 weeks a level of virus in their blood below the level of detectability using very sensitive viral load testing. At some point during their follow-up, six patients tested negative for the HIV virus using standard HIV antibody tests.


Hare presented the study at the XV International AIDS Conference in Bangkok, Thailand on July 12.

Study participants were selected from the Options Project Cohort. Patients in this cohort enter the study in either primary or early infection -- meaning no patient had been infected with the HIV virus for more than six months.

The six patients who tested negative for the HIV virus were tested using standard second- and third-generation Enzyme Immunoassays, which are the most commonly used tests to screen for HIV infection, and Western Blot tests, which are the most commonly used tests for confirming HIV infection.

Co-authors for the study are Brandee Pappalardo, PhD, MPH, staff scientist at the Blood Systems Research Institute, San Francisco; Bruce Phelps, Chiron Corporation, Emeryville, CA; Steven S. Alexander, Ortho Clinical Diagnostics, Raritan, NJ; Clarissa Ramstead, nurse practitioner at the UCSF PHP; Jay A. Levy, UCSF professor of medicine and director of the Laboratory for Tumor and AIDS Virus Research; Frederick M. Hecht, MD, associate clinical professor of medicine at the UCSF PHP; Michael P. Busch, MD, PhD, vice president, Research & Scientific Services, Blood Centers of the Pacific, and UCSF adjunct professor of laboratory medicine.

Funding for this research was provided by grants from the National Institutes of Health and the Centers for Disease Control.

The Positive Health Program is a component of the UCSF AIDS Research Institute (ARI). UCSF ARI houses hundreds of scientists and dozens of programs throughout UCSF and affiliated labs and institutions, making ARI one of the largest AIDS research entities in the world.

Jeff Sheehy | EurekAlert!
Further information:
http://www.ucsf.edu

More articles from Health and Medicine:

nachricht Research reveals how diabetes in pregnancy affects baby's heart
13.12.2017 | University of California - Los Angeles Health Sciences

nachricht Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Gecko adhesion technology moves closer to industrial uses

13.12.2017 | Information Technology

Columbia engineers create artificial graphene in a nanofabricated semiconductor structure

13.12.2017 | Physics and Astronomy

Research reveals how diabetes in pregnancy affects baby's heart

13.12.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>