The bacterium, Helicobacter pylori, which infects the stomach, causes duodenal ulcer disease and is thought to cause stomach cancer. The question of why the bacteria are only found in the stomach has puzzled scientists for many years. Researchers at the Conway Institute and the Children’s Research Centre at Our Lady’s Hospital for Sick Children, Dublin in collaboration with workers at The National Centre for Sensor Research, Dublin City University and The University of Newcastle upon Tyne, UK have discovered the answer and their findings have been published in the current issue of The Proceedings of the National Academy of Sciences.
A family of small proteins called trefoil factors (TFF) are found in the mucous overlying stomach cells. Their job is to protect the stomach cells from harm. A team of researchers led by Dr Marguerite Clyne and Professor Brendan Drumm have now identified that one member of this family (TFF1) acts as a receptor or docking station for the bacteria and helps them to attach to the surface of the stomach. Within the gastrointestinal tract, this receptor is normally found only in the stomach, which would explain why H. pylori only infects the stomach and not the intestine or colon.
The World Health Organisation classifies H. pylori as a class I cancer causing agent. Epidemiological studies carried out by the H. pylori research group at the Conway Institute have shown that infection with the bacteria almost always occurs in early childhood rather than in adult life. Unless treated, it continues to infect the individual throughout their lives causing ulcer disease or cancer of the stomach in some individuals later in life. Gastric cancer is the fourth most common cause of death from cancer in the world.
Elaine Quinn | alfa
Inflammation Triggers Unsustainable Immune Response to Chronic Viral Infection
24.10.2016 | Universität Basel
Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
24.10.2016 | Earth Sciences
24.10.2016 | Life Sciences
24.10.2016 | Physics and Astronomy