Researchers at the University of Warwick have for the first time been able to detail how and why specific neurons in the brain control the hunger response. They have revealed a set of pacemaker nerve cells in the brain that appear to underlie the drive to feed which itself feeds on a complex web of signals. The level of complexity they have found is such that the system could be much more at risk of serious repercussions from a single error in how those signals are processed than anyone had previously thought. Any number of a range of errors could lead to over activity of these pacemaker cells and explain why many people find difficulty in eating less.
In the research, published in the May Issue of Nature Neuroscience, Dr David Spanswick and his research team in the University of Warwick’s Department of Biological Sciences, looked at a part of the brain called the hypothalamic arcuate nucleus which was known to deal with hunger and satiety signals but how it achieves this is poorly understood. The University of Warwick team have identified very specific neurons that act as feeding pacemakers.
This specific group of neurons- which they have dubbed the ARC pacemaker produce regular bursts of electrical activity. However these cells integrate and process a wide variety of signals indicating the energy needs of the body signals most often transmitted by the use of chemical messengers such as hormones like ghrelin, released from the gut and leptin from fat cells. The combination of these signals and their integration by the ARC pacemaker is such a finely balanced mechanism that one small error or mutation leading to any inappropriate communication in these pathways could produce a significant untoward affect on human eating or feeding patterns.
Peter Dunn | University of Warwick
Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital
New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
12.12.2017 | Physics and Astronomy
12.12.2017 | Earth Sciences
12.12.2017 | Power and Electrical Engineering