Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New insight into how tumors evade the immune system

23.03.2004


A new research study sheds light on how cancer cells manage to evade the immune system despite the presence of tumor-specific immune cells. The researchers found that mouse and human melanoma cells secrete galectin-1, which has a negative impact on the survival of T cells, and that inhibition of Gal-1 dramatically reduces tumor formation in mice. The research has exciting implications for future anticancer therapies that may stimulate an effective immune response against tumor cells.



Tumor cells enhance their own survival by somehow escaping attacks from the immune system of the host. A molecule called galectin-1 (Gal-1) has a negative influence on immune cells called T cells and is present in many different tumor types, especially aggressive cancers like prostate, colon, and ovarian carcinomas and melanoma. Dr. Gabriel A. Rabinovich from the University of Buenos Aires in Argentina and colleagues designed a study to look at how Gal-1 may contribute to the interaction between tumor cells and the host environment. The researchers found that mouse and human melanoma cells secrete Gal-1and demonstrated that Gal-1 has a negative impact on the survival of T cells. Further, inhibition of Gal-1 can dramatically reduce tumor formation in mice challenged with cancer cells.

The researchers conclude that Gal-1-dependent mechanisms play a critical role in the ability of tumors to overwhelm cancer-fighting T cells. "Our results show that Gal-1 contributes to immune privilege of tumors by modulating survival and/or polarization of effector T cells, providing the first concrete evidence of a link between the immunoregulatory properties of this protein and its contribution to tumor progression. More importantly, our data highlight a novel molecular target for manipulation of T cell tolerance and cell death with profound implications for cancer immunotherapy," explains Dr. Rabinovich.


Natalia Rubinstein, Mariano Alvarez, Norberto W. Zwirner, Marta A. Toscano, Juan M. Ilarregui, Alicia Bravo, José Mordoh, Leonardo Fainboim, Osvaldo L. Podhajcer, and Gabriel A. Rabinovich: "Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection: A potential mechanism of tumor-immune privilege"


Published in Cancer Cell, Volume 5, Number 3, March 2004, pages 241-252.

Heidi Hardman | EurekAlert!
Further information:
http://www.cell.com/

More articles from Health and Medicine:

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

nachricht Disrupted fat breakdown in the brain makes mice dumb
19.05.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

Im Focus: Hydrogen Bonds Directly Detected for the First Time

For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.

Hydrogen is the most common element in the universe and is an integral part of almost all organic compounds. Molecules and sections of macromolecules are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

Media accreditation opens for historic year at European Health Forum Gastein

16.05.2017 | Event News

 
Latest News

New approach to revolutionize the production of molecular hydrogen

22.05.2017 | Materials Sciences

Scientists enlist engineered protein to battle the MERS virus

22.05.2017 | Life Sciences

Experts explain origins of topographic relief on Earth, Mars and Titan

22.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>