Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New insight into how tumors evade the immune system

23.03.2004


A new research study sheds light on how cancer cells manage to evade the immune system despite the presence of tumor-specific immune cells. The researchers found that mouse and human melanoma cells secrete galectin-1, which has a negative impact on the survival of T cells, and that inhibition of Gal-1 dramatically reduces tumor formation in mice. The research has exciting implications for future anticancer therapies that may stimulate an effective immune response against tumor cells.



Tumor cells enhance their own survival by somehow escaping attacks from the immune system of the host. A molecule called galectin-1 (Gal-1) has a negative influence on immune cells called T cells and is present in many different tumor types, especially aggressive cancers like prostate, colon, and ovarian carcinomas and melanoma. Dr. Gabriel A. Rabinovich from the University of Buenos Aires in Argentina and colleagues designed a study to look at how Gal-1 may contribute to the interaction between tumor cells and the host environment. The researchers found that mouse and human melanoma cells secrete Gal-1and demonstrated that Gal-1 has a negative impact on the survival of T cells. Further, inhibition of Gal-1 can dramatically reduce tumor formation in mice challenged with cancer cells.

The researchers conclude that Gal-1-dependent mechanisms play a critical role in the ability of tumors to overwhelm cancer-fighting T cells. "Our results show that Gal-1 contributes to immune privilege of tumors by modulating survival and/or polarization of effector T cells, providing the first concrete evidence of a link between the immunoregulatory properties of this protein and its contribution to tumor progression. More importantly, our data highlight a novel molecular target for manipulation of T cell tolerance and cell death with profound implications for cancer immunotherapy," explains Dr. Rabinovich.


Natalia Rubinstein, Mariano Alvarez, Norberto W. Zwirner, Marta A. Toscano, Juan M. Ilarregui, Alicia Bravo, José Mordoh, Leonardo Fainboim, Osvaldo L. Podhajcer, and Gabriel A. Rabinovich: "Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection: A potential mechanism of tumor-immune privilege"


Published in Cancer Cell, Volume 5, Number 3, March 2004, pages 241-252.

Heidi Hardman | EurekAlert!
Further information:
http://www.cell.com/

More articles from Health and Medicine:

nachricht NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University

nachricht How to turn white fat brown
07.12.2016 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

NTU scientists build new ultrasound device using 3-D printing technology

07.12.2016 | Health and Medicine

The balancing act: An enzyme that links endocytosis to membrane recycling

07.12.2016 | Life Sciences

How to turn white fat brown

07.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>