Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New insight into how tumors evade the immune system

23.03.2004


A new research study sheds light on how cancer cells manage to evade the immune system despite the presence of tumor-specific immune cells. The researchers found that mouse and human melanoma cells secrete galectin-1, which has a negative impact on the survival of T cells, and that inhibition of Gal-1 dramatically reduces tumor formation in mice. The research has exciting implications for future anticancer therapies that may stimulate an effective immune response against tumor cells.



Tumor cells enhance their own survival by somehow escaping attacks from the immune system of the host. A molecule called galectin-1 (Gal-1) has a negative influence on immune cells called T cells and is present in many different tumor types, especially aggressive cancers like prostate, colon, and ovarian carcinomas and melanoma. Dr. Gabriel A. Rabinovich from the University of Buenos Aires in Argentina and colleagues designed a study to look at how Gal-1 may contribute to the interaction between tumor cells and the host environment. The researchers found that mouse and human melanoma cells secrete Gal-1and demonstrated that Gal-1 has a negative impact on the survival of T cells. Further, inhibition of Gal-1 can dramatically reduce tumor formation in mice challenged with cancer cells.

The researchers conclude that Gal-1-dependent mechanisms play a critical role in the ability of tumors to overwhelm cancer-fighting T cells. "Our results show that Gal-1 contributes to immune privilege of tumors by modulating survival and/or polarization of effector T cells, providing the first concrete evidence of a link between the immunoregulatory properties of this protein and its contribution to tumor progression. More importantly, our data highlight a novel molecular target for manipulation of T cell tolerance and cell death with profound implications for cancer immunotherapy," explains Dr. Rabinovich.


Natalia Rubinstein, Mariano Alvarez, Norberto W. Zwirner, Marta A. Toscano, Juan M. Ilarregui, Alicia Bravo, José Mordoh, Leonardo Fainboim, Osvaldo L. Podhajcer, and Gabriel A. Rabinovich: "Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection: A potential mechanism of tumor-immune privilege"


Published in Cancer Cell, Volume 5, Number 3, March 2004, pages 241-252.

Heidi Hardman | EurekAlert!
Further information:
http://www.cell.com/

More articles from Health and Medicine:

nachricht Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>