Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


The catch 22 of immune response to AIDs viral infection


A strong antigen-specific T-cell response to HIV infection is important for controlling virus replication; however, because HIV selectively infects and replicates in CD4 T cells, increased number of these cells in response to viral infection may also be detrimental as these cells provide fuel for the infection to grow.

In the March 15 issue of the Journal of Clinical Investigation, Mark Feinberg and colleagues, of Emory University Vaccine Center, analyze the specific parameters of T-cell activation that may be harmful or helpful in fighting HIV infection by looking at simian immunodeficiency viral (SIV) replication in rhesus macaques where they have blocked CD4 and CD8 T-cell co-stimulation pathways.

The study provides clear evidence for an important role in the immune activation level directly affects the initial peak of virus in the blood stream. They further show that the steady-state viral levels in chronic infection are directly related to the generation of a primary immune response.

Evidence in this study also indicates, indirectly, that immunological response may indeed be harmful by providing increased numbers of target cells for infection. The work here presents the first set of data to differentiate between helpful and harmful effects of the immune response to HIV, and may therefore contribute to new strategies for combating this disease.

An accompanying commentary by Bruce Walker (Harvard Medical School) and Steven Deeks (University of California, San Francisco) provides a detailed discussion of the different components of the findings and how these results aid in picking apart this complex interplay between HIV infection and our immune response.

Laurie Goodman | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht Advanced analysis of brain structure shape may track progression to Alzheimer's disease
26.10.2016 | Massachusetts General Hospital

nachricht Indian roadside refuse fires produce toxic rainbow
26.10.2016 | Duke University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel light sources made of 2D materials

Physicists from the University of Würzburg have designed a light source that emits photon pairs. Two-photon sources are particularly well suited for tap-proof data encryption. The experiment's key ingredients: a semiconductor crystal and some sticky tape.

So-called monolayers are at the heart of the research activities. These "super materials" (as the prestigious science magazine "Nature" puts it) have been...

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Prototype device for measuring graphene-based electromagnetic radiation created

28.10.2016 | Power and Electrical Engineering

Gamma ray camera offers new view on ultra-high energy electrons in plasma

28.10.2016 | Physics and Astronomy

When fat cells change their colour

28.10.2016 | Life Sciences

More VideoLinks >>>