Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Hopkins researchers find MRI useful tool in diagnosing inflammatory bowel diseases in children

05.03.2004


Magnetic resonance imaging (MRI), coupled with the use of the contrast dye gadolinium, may help pediatricians better diagnose children with ulcerative colitis and Crohn’s disease, according to a study by researchers at the Johns Hopkins Children’s Center.



Results of the study, published in the March issue of Inflammatory Bowel Diseases, showed that the gadolinium-enhanced MRI (G-MRI) confirmed these diagnoses in more than 90 percent of the children in the study who had inflammatory bowel disease (IBD). Because ulcerative colitis and Crohn’s disease -- two painful ailments with similar origins and symptoms -- have two very different treatment regimens, especially if surgical treatment is contemplated, early diagnosis is critical, the researchers say.

"For the most severe cases of ulcerative colitis, surgical removal of the colon is the only cure, while there is no cure for Crohn’s disease," says Anil Darbari, M.D., a pediatric gastroenterologist at the Children’s Center, and the lead author of the study. "Unfortunately, many children who are originally diagnosed with ulcerative colitis and have their diseased colon surgically removed are later found to actually have had Crohn’s, which is discovered when the disease resurfaces in another area within the intestinal tract."


"We also found that G-MRI was very helpful in diagnosing pediatric small bowel disease, which occurs in an area in a child’s body that is not accessible by conventional endoscopies or colonoscopies," Darbari says. "Because children with small bowel disease may not exhibit traditional Crohn’s disease symptoms, finding definitive evidence of small bowel disease, which is affiliated with Crohn’s disease, prevents these children from being labeled with indeterminate IBD and allows them to begin the appropriate drug treatment right away."

Previous studies have shown G-MRI is effective in distinguishing Crohn’s disease and ulcerative colitis in adults. However, this is believed to be the first study to establish G-MRI as a radiological tool in diagnosing IBD in children.

In the study, pediatric radiologists at the Johns Hopkins Children’s Center performed a G-MRI on 58 children with suspected IBD between 1999 and 2002. Researchers used intravenous gadolinium -- a safe, commonly used contrast dye -- and other standard imaging tools to enhance the image of the intestinal wall.

Based on G-MRI results, 30 children were classified with having Crohn’s disease, eight with ulcerative colitis, six with possible Crohn’s disease, and 14 as having neither disease. Researchers compared these findings with those from more traditional IBD diagnostic tests, including colonoscopy, in which a tiny scope is inserted through the rectum to examine the lower digestive tract; computerized tomography (CT), which creates a 3-D image of the intestines; small bowel image studies; and biopsied colon tissue. They discovered G-MRI confirmed the diagnosis of ulcerative colitis in 92 percent of patients and the diagnosis of Crohn’s disease in 96 percent of patients.

G-MRI is unlikely to replace colonoscopy, says Darbari, because colonoscopy allows tissue samples to be obtained and biopsied for further evaluation. However, he adds, for children with suspected small bowel disease, G-MRI does provide a more sensitive, non-invasive, diagnostic tool and could replace conventional CT and small bowel contrast studies.

Crohn’s disease and ulcerative colitis primarily affect the intestines, resulting in pain, severe diarrhea, intestinal bleeding, weight loss and fever. Symptoms vary in severity and duration; some patients suffer from frequent prolonged attacks, and others have fewer recurrences. Both diseasea usually startsin adolescence or young adulthood, but can also be seen in younger children. In ulcerative colitis, the inner lining of the colon is inflamed. People with Crohn’s disease have similar inflammation, but it extends deeper into the intestinal wall and can also involve the small and large intestines.


The study was supported in part by the Crohn’s and Colitis Foundation of America First Award and The Thomas Wilson Sanitarium Awards. Co-authors of the study were Laureen Sena, M.D., and Carmen Cuffari, M.D. of the Johns Hopkins Children’s Center; and Richard Thompson, Ph.D. of the Johns Hopkins School of Public Health.

Jessica Collins | EurekAlert!
Further information:
http://www.hopkinsmedicine.org/

More articles from Health and Medicine:

nachricht Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University

nachricht ASU scientists develop new, rapid pipeline for antimicrobials
14.12.2017 | Arizona State University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Plasmonic biosensors enable development of new easy-to-use health tests

14.12.2017 | Health and Medicine

New type of smart windows use liquid to switch from clear to reflective

14.12.2017 | Physics and Astronomy

BigH1 -- The key histone for male fertility

14.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>