Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New index measures risk of death from blood clot

02.03.2004


Predicting the mortality of patients with pulmonary emboli (blood clots in the lung) may become possible with a newly developed clot-volume ranking index, according to a study appearing in the March issue of the journal Radiology.



"We found that the amount of clot present is predictive of patient outcome," said study coauthor, John A. Pezzullo, M.D., assistant professor of diagnostic imaging at Brown University in Providence, R.I. "Consequently, patients with a high clot volume have a poor prognosis."

Quantification of clot size with the pulmonary arterial obstruction index, called the CTPE Index, allows physicians to triage pulmonary embolism (PE) patients based on risk. This is the first attempt to relate the clot volume, or burden, to the clinical outcome. Little consideration has previously been given to the implication of clot load on therapy.


The researchers used the CTPE Index to retrospectively evaluate multi-detector row computed tomography (MDCT) studies of 59 patients with PE to determine if a correlation exists between pulmonary embolus volume and survival. They found that patients with a clot burden of 60 percent (scoring 24 points out of 40) or greater, as determined by the CTPE Index, are at increased risk of death and may require aggressive treatment such as catheter-directed thrombolysis or thrombolytic therapy in intensive care.

Five of the six patients (83 percent) with large clots indicated by a CTPE Index of 60 percent or greater died, while all but one of the 53 patients (98 percent) with a CTPE Index of less than 60 percent survived.

PE is a serious medical issue in the United States, with approximately 600,000 new cases diagnosed annually and nearly 50,000 deaths yearly, according to Dr. Pezzullo.

"In the future, emergency department patients with pulmonary embolism will be stratified by risk based on how large the clot burden is," Dr. Pezzullo said. "Patients who have very high clot burdens may be treated more aggressively than patients with minimal burdens."

CT pulmonary angiography, a noninvasive test that allows high resolution imaging of lung vessels, is replacing conventional pulmonary angiography as a first line exam for detecting pulmonary emboli. Studies show CT to be more cost effective than the more invasive conventional angiography in the work-up of suspected lung blood clots.

The researchers note that this is a preliminary study, and larger trials need to be developed to validate the results.


Radiology is a monthly scientific journal devoted to clinical radiology and allied sciences. The journal is edited by Anthony V. Proto, M.D., School of Medicine, Virginia Commonwealth University, Richmond, Virginia. Radiology is owned and published by the Radiological Society of North America Inc. (http://radiology.rsnajnls.org)

The Radiological Society of North America is an association of more than 35,000 radiologists, radiation oncologists and related scientists committed to promoting excellence in radiology through education and by fostering research, with the ultimate goal of improving patient care. The Society is based in Oak Brook, Ill. (http://www.rsna.org)

"CT Pulmonary Angiography: Quantification of Pulmonary Embolus As a Predictor of Patient Outcome - Initial Experience." Collaborating with Dr. Pezzullo on this study were Andrew S. Wu, B.A., John J. Cronan, M.D., David D. Hou, M.D., and William W. Mayo-Smith, M.D.

Maureen Morley | EurekAlert!
Further information:
http://radiology.rsnajnls.org

More articles from Health and Medicine:

nachricht Vanishing capillaries
23.03.2017 | Technische Universität München

nachricht How prenatal maternal infections may affect genetic factors in Autism spectrum disorder
22.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short

23.03.2017 | Life Sciences

Researchers use light to remotely control curvature of plastics

23.03.2017 | Power and Electrical Engineering

Sea ice extent sinks to record lows at both poles

23.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>