Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study confirms benefits of hemispherectomy surgery

14.10.2003


A new study by Johns Hopkins Children’s Center scientists confirms the lasting benefits of hemispherectomy, a dramatic operation in which half the brain is removed to relieve frequent severe seizures that medications cannot control.



Results of the study, published in the Oct. 14 issue of Neurology, show that 86 percent of the 111 children who underwent hemispherectomy at the Children’s Center between 1975 and 2001 are either seizure-free or have non-disabling seizures that do not require medication.

These results are slightly improved over a 1997 study of 58 Hopkins hemispherectomy patients which found that 78 percent of children were either seizure-free or had mild seizures.


The findings should help parents who are still contemplating whether their child would benefit from the surgery, said the study’s lead author, Eric Kossoff, M.D., a pediatric epileptologist at the Children’s Center.

"It’s clear now that the quality of life of children with chronic, severe seizures greatly improves following hemispherectomy," he said. "In almost all cases, the children no longer depend on multiple medications, and post-operatively, most of the children are walking and running and living normal lives."

All hemispherectomy patients have partial paralysis on the side of the body opposite the removed portion. However, "except for a few with major postoperative complications, such as meningitis and edema, all the children we followed up with are up and about and most have adapted to their handicapped side so well that they play the piano, golf, ping-pong and can dance," Kossoff added.

In the latest study, Hopkins researchers reviewed the charts and contacted many of the families of the 58 children who participated in the 1997 study, as well as 53 other children who subsequently had a Hopkins hemispherectomy. They found 65 percent are seizure-free, 21 percent have occasional, non-handicapping seizures, and 14 percent have troublesome seizures. Eighty percent of patients no longer use drugs or are taking only one anti-convulsant medication.

The researchers say patients with Rasmussen’s syndrome, a rare nervous system disorder characterized by chronic inflammation of the brain, and those with congenital vascular injuries benefit the most from hemispherectomy. Sixty-five percent of Rasmussen’s patients and 81 percent of patients with vascular injuries are now seizure-free.

Although children with disorders of brain development (dysplasias) have just a 50/50 chance of being seizure-free following the surgery, even those with persistent seizures after surgery experience a reduction in the number of seizures, Kossoff said.

The surgery, which leaves intact the deep structures of the brain (the thalamus, brain stem and basal ganglia), is performed at Hopkins on children with Rasmussen’s syndrome, a variety of developmental abnormalities on one side of the brain, and on those who have had disabling strokes. Because children’s brains are "plastic," if surgeons remove the affected portion of the brain, the remaining portion overtakes most of the functions of the missing side.

Hemispherectomy was first attempted in the 1920s by Hopkins neurosurgeon Walter E. Dandy, M.D. It was reintroduced at Hopkins in 1968 and was refined in the 1980s by Benjamin S. Carson, M.D., director of pediatric neurosurgery at the Children’s Center and a co-author of the current study.

Additional co-authors are Eileen P.G. Vining, Diana J. Pillas, Paula L. Pyzik, Anthony M. Avellino, and John M. Freeman, all of the department of pediatric neurology and neurosurgery at the Johns Hopkins Children’s Center. (Dr. Avellino is now on the faculty at the University of Washington School of Medicine.)


The study was supported in part by The Roxanne Fund.


Johns Hopkins Medicine
Office of Communications and Public Affairs
Media Contact: Jessica Collins (410) 516-4570
Email: jcolli31@jhmi.edu

Jessica Collins | EurekAlert!
Further information:
http://www.hopkinsmedicine.org/

More articles from Health and Medicine:

nachricht Nanoparticles as a Solution against Antibiotic Resistance?
15.12.2017 | Friedrich-Schiller-Universität Jena

nachricht Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>