Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers discover new genetic link to common colon cancer

14.10.2003


Blood from families at risk contributed to discovery



A team of researchers from University Hospitals of Cleveland (UHC) and Case Western Reserve University have identified a specific location on a human chromosome that can be linked to familial cases of colon cancer--the type of colon cancer that tends to run in families.

Research published today in the Proceedings of the National Academy of Sciences (PNAS article #2286) identifies a specific stretch of DNA on chromosome 9 that houses a "susceptibility" gene. "Previous studies have shown that colon cancer risk can be inherited," says Sanford Markowitz, MD, principal investigator for the study. "By analyzing blood samples from 53 families, in which at least one member of the family had a colon cancer or pre-cancerous colon polyp, we were able to find a common link. This moves us much closer to developing a blood test that will identify people who are susceptible to colon cancer well before the cancer ever develops." Dr. Markowitz is a professor of cancer genetics at Case, a Howard Hughes Medical Institute investigator, and treats patients at University Hospitals Ireland Cancer Center.


Georgia Wiesner, MD, Director of the Center for Human Genetics at UHC and Case, and lead author of the study, notes that at least 200 genes exist on this particular location on chromosome 9. "Future research will focus on finding the one responsible gene," says Dr. Wiesner. "The research team is looking for more sibling pairs and family members for the crucial next phase of the study, the actual identification of the disease-causing gene."

In addition to Drs. Markowitz and Wiesner, the research team included Robert Elston, PhD, of the Department of Epidemiology and Biostatistics at Case, and Joseph Willis, MD, of the Department of Pathology at Case and UHC.

More than six years ago, Cleveland researchers began to recruit study participants who had at least one sibling affected with colorectal cancer or large colon polyps (adenomas, which are precursors to cancer) before the age of 65. Participants provided a sample of blood and underwent colon cancer screening. In some cases, study participants who had no symptoms of disease were discovered to have pre-cancerous polyps, and had them removed. Thus, participation in the study itself actually helped some high-risk patients avoid developing colon cancer.

Colon cancer is the second leading cause of cancer death among Americans. Studies have shown that nearly 30% of adults over age 50 have non-symptomatic polyps in the colon, precursors to cancer. Studies also show that brothers and sisters of individuals with colon polyps or cancer have triple the average risk for developing colon cancer themselves.

Previously, researchers at University Hospitals of Cleveland and Case discovered a genetic link to a rare form of colon cancer called Hereditary Nonpolyposis Colon Cancer (HNPCC) that tends to develop in young adults in certain families. The just-published study was designed to identify a genetic connection in more common colon cancers. The "Colon Cancer Sibling Study" combined the expertise of physicians and scientists from the departments of Genetics, Medicine (Oncology and Gastroenterology), Pathology, Epidemiology and Biostatistics at Case and UHC.

The current study received significant support from the National Cancer Institute, the National Colon Cancer Research Alliance (NCCRA) of the Entertainment Industry Foundation, and the Howard Hughes Medical Institute. Anyone interested in participating in the next phase of the "Sibling Study" should contact the Ireland Cancer Center Information Service at University Hospitals at 1-800-641-2422. The goal is to recruit 150 new families into the study to "ultimately provide identification of the putative disease gene that underlies this linkage."


Media inquiries should be directed to Eileen Korey, Director of News Services at University Hospitals of Cleveland at 216-844-3825 or George Stamatis, Director of Public Affairs at Case School of Medicine at 216-368-3635.

Eileen Korey | EurekAlert!
Further information:
http://www.uhhs.com/

More articles from Health and Medicine:

nachricht TSRI researchers develop new method to 'fingerprint' HIV
29.03.2017 | Scripps Research Institute

nachricht Periodic ventilation keeps more pollen out than tilted-open windows
29.03.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Researchers shoot for success with simulations of laser pulse-material interactions

29.03.2017 | Materials Sciences

Igniting a solar flare in the corona with lower-atmosphere kindling

29.03.2017 | Physics and Astronomy

As sea level rises, much of Honolulu and Waikiki vulnerable to groundwater inundation

29.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>