Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Understanding Alzheimer’s disease: Animal research points to new direction for therapy

06.10.2003


Saint Louis University study suggests protein can´t cross blood brain barrier


ST. LOUIS -- Alzheimer´s disease may be caused by a problem transporting a certain protein across the blood brain barrier and out of the brain, according to new Saint Louis University research published in the October issue of Neuroscience.

The findings are important, says William A. Banks, M.D., a Saint Louis University professor and the lead author of the article, because they give us a new approach for treating Alzheimer´s disease.

"It´s going to be a big piece to solving the Alzheimer´s disease puzzle," says Dr. Banks, a professor of geriatrics in the department of internal medicine and professor of pharmacological science at Saint Louis University School of Medicine. "If one could reverse the transport deficit problem, the system should be able to pump the protein out again. The impaired transporter problem may be an easier therapeutic target."



Normally, amyloid beta protein, the protein thought to cause Alzheimer´s disease, leaves the brain and crosses the blood brain barrier, which is a wall of blood vessels that feed the brain and regulate the entry and exit of brain chemicals. But in persons with Alzheimer´s disease, amyloid beta protein becomes blocked in the brain and can´t make it across the blood brain barrier. The more amyloid beta protein accumulates, the tougher it is for the blood brain barrier to move it out, and the more disabled a person becomes.

Because the transport deficit causes the amyloid beta protein to accumulate, scientists should focus on finding ways to destroy the protein with enzymes or pushing the protein across the blood brain barrier and out of the brain. Dr. Banks says fixing the system that transports amyloid beta protein across the blood brain barrier is "a viable therapeutic target."

"We need to find therapies to bring the transportation system back on line to pump the amyloid beta protein out of the brain," says Dr. Banks, who also is a staff physician at Veterans Affairs Medical Center in St. Louis.

The research analyzed the accumulation of amyloid beta protein in a mouse model of Alzheimer´s disease.

Nancy Solomon | EurekAlert!

More articles from Health and Medicine:

nachricht A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital

nachricht Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

Im Focus: Quantum-physical Model System

Computer-assisted methods aid Heidelberg physicists in reproducing experiment with ultracold atoms

Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...

Im Focus: Glacier bacteria’s contribution to carbon cycling

Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.

A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

New quantum liquid crystals may play role in future of computers

21.04.2017 | Physics and Astronomy

A promising target for kidney fibrosis

21.04.2017 | Health and Medicine

Light rays from a supernova bent by the curvature of space-time around a galaxy

21.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>