A Duke University research collaboration has identified a likely route for "leakage" of therapeutic gene-bearing viruses out of tumors in experimental anti-cancer gene therapy experiments in laboratory animals. The group also found this toxic leakage can be avoided by using a chemical extracted from common brown algae.
Their work was described in a 9:30 a.m. Sept. 8 presentation at the American Chemical Societys national meeting in New York, as well as in a research paper accepted for publication in the journal Molecular Cancer Therapeutics.
Investigators from the biomedical engineering department at Dukes Pratt School of Engineering and the radiation oncology department at the Duke Medical Center collaborated to trace why high concentrations of the protein produced by the therapeutic genes were present in the wrong places during animal experiments directed against tumors.
Monte Basgall | EurekAlert!
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