Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Long-term survival after breast cancer diagnosis

02.06.2003


Most breast cancer patients with more than 10 nodes that are affected by the cancer have a poor prognosis, yet some survive long-term. Physicians now believe that certain genes in the breast cancer tissue, removed at diagnosis, can help them predict which patients will survive.



With this information, doctors can recommend the most appropriate therapy for an individual patient, for example sparing a woman with a poor prognosis the rigors that accompany aggressive chemotherapy, and enabling her to receive novel treatments that might work, according to Dr. Melody Cobleigh, oncologist, professor of medicine and director of the Comprehensive Breast Center at Rush-Presbyterian-St. Luke’s Medical Center in Chicago.

Cobleigh presented her research results on May 31 at the American Society of Clinical Oncology Annual Meeting in Chicago. Until now, such studies could only be performed on recently biopsied tissue that would then be frozen for preservation. Routine handling of cancer specimens does not involve freezing. Cobleigh and colleagues at Genomic Health examined the breast cancer tissue of 79 patients who had been treated at Rush between 1979 and 1999 and whose tissues had been processed in the usual manner (formalin-fixed and paraffin-embedded). The patients had been followed for a median of 15 years.


Expression of 185 cancer-related genes was assessed. The genes chosen were based on previous reports on frozen tissues. Cobleigh determined that those women whose tumors expressed excess amounts of some genes, e.g. TP53BP2, PR and Bcl2, were more likely to be free of cancer in their vital organs. She also found that women whose tumors expressed too much of other genes, e.g. GRB7, CTSL and DIABLO experienced a worse outcome. Cobleigh reported that even among women with 10 or more positive nodes, the gene expression profile could predict long-term survival.

"Until now, the only indications we have had of long-term prognosis were tumor size and the number of involved nodes," Cobleigh said. "This technology will allow us to tailor a prognosis to the individual patient, using information from thousands of genes."

She cautioned, however, that her research is a first step. "These findings must be confirmed in independent data sets," she said. She pointed out, however, that this is already underway, using material from tumor banks owned and managed by international cooperative groups, such as the National Surgical Adjuvant Breast and Bowel Project (NSABP), which is a clinical trials cooperative group supported by the National Cancer Institute (NCI). If results are validated, the test could become commercially available within a year.

Cobleigh, who was an investigator in the 1990s on the clinical trials to test the monoclonal antibody Herceptin, suggested that another offshoot of this work is to examine the tumor for expression of genes that will predict responsiveness to specific therapies, such as Herceptin.

Tumor tissue for this research was generated from the Bill Shorey Database of Breast Tumors, named after Dr. Bill Shorey, a breast surgeon who worked at Rush for more than 30 years. The Shorey Database was computerized by Dr. David Roseman, another surgeon who worked at Rush for over 30 years, and Michigan physician Dr. Craig Silverton.


Rush-Presbyterian-St. Luke’s Medical Center includes the 824-bed Presbyterian-St. Luke’s Hospital; 110-bed Johnston R. Bowman Health Center; Rush University (Rush Medical College, College of Nursing, College of Health Sciences and the Graduate College).

Chris Martin | EurekAlert!
Further information:
http://www.rush.edu/

More articles from Health and Medicine:

nachricht Cystic fibrosis alters the structure of mucus in airways
29.06.2017 | University of Iowa Health Care

nachricht Mice provide insight into genetics of autism spectrum disorders
28.06.2017 | University of California - Davis

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making Waves

Computer scientists use wave packet theory to develop realistic, detailed water wave simulations in real time. Their results will be presented at this year’s SIGGRAPH conference.

Think about the last time you were at a lake, river, or the ocean. Remember the ripples of the water, the waves crashing against the rocks, the wake following...

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Nanostructures taste the rainbow

29.06.2017 | Physics and Astronomy

New technique unveils 'matrix' inside tissues and tumors

29.06.2017 | Life Sciences

Cystic fibrosis alters the structure of mucus in airways

29.06.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>