Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Long-term survival after breast cancer diagnosis

02.06.2003


Most breast cancer patients with more than 10 nodes that are affected by the cancer have a poor prognosis, yet some survive long-term. Physicians now believe that certain genes in the breast cancer tissue, removed at diagnosis, can help them predict which patients will survive.



With this information, doctors can recommend the most appropriate therapy for an individual patient, for example sparing a woman with a poor prognosis the rigors that accompany aggressive chemotherapy, and enabling her to receive novel treatments that might work, according to Dr. Melody Cobleigh, oncologist, professor of medicine and director of the Comprehensive Breast Center at Rush-Presbyterian-St. Luke’s Medical Center in Chicago.

Cobleigh presented her research results on May 31 at the American Society of Clinical Oncology Annual Meeting in Chicago. Until now, such studies could only be performed on recently biopsied tissue that would then be frozen for preservation. Routine handling of cancer specimens does not involve freezing. Cobleigh and colleagues at Genomic Health examined the breast cancer tissue of 79 patients who had been treated at Rush between 1979 and 1999 and whose tissues had been processed in the usual manner (formalin-fixed and paraffin-embedded). The patients had been followed for a median of 15 years.


Expression of 185 cancer-related genes was assessed. The genes chosen were based on previous reports on frozen tissues. Cobleigh determined that those women whose tumors expressed excess amounts of some genes, e.g. TP53BP2, PR and Bcl2, were more likely to be free of cancer in their vital organs. She also found that women whose tumors expressed too much of other genes, e.g. GRB7, CTSL and DIABLO experienced a worse outcome. Cobleigh reported that even among women with 10 or more positive nodes, the gene expression profile could predict long-term survival.

"Until now, the only indications we have had of long-term prognosis were tumor size and the number of involved nodes," Cobleigh said. "This technology will allow us to tailor a prognosis to the individual patient, using information from thousands of genes."

She cautioned, however, that her research is a first step. "These findings must be confirmed in independent data sets," she said. She pointed out, however, that this is already underway, using material from tumor banks owned and managed by international cooperative groups, such as the National Surgical Adjuvant Breast and Bowel Project (NSABP), which is a clinical trials cooperative group supported by the National Cancer Institute (NCI). If results are validated, the test could become commercially available within a year.

Cobleigh, who was an investigator in the 1990s on the clinical trials to test the monoclonal antibody Herceptin, suggested that another offshoot of this work is to examine the tumor for expression of genes that will predict responsiveness to specific therapies, such as Herceptin.

Tumor tissue for this research was generated from the Bill Shorey Database of Breast Tumors, named after Dr. Bill Shorey, a breast surgeon who worked at Rush for more than 30 years. The Shorey Database was computerized by Dr. David Roseman, another surgeon who worked at Rush for over 30 years, and Michigan physician Dr. Craig Silverton.


Rush-Presbyterian-St. Luke’s Medical Center includes the 824-bed Presbyterian-St. Luke’s Hospital; 110-bed Johnston R. Bowman Health Center; Rush University (Rush Medical College, College of Nursing, College of Health Sciences and the Graduate College).

Chris Martin | EurekAlert!
Further information:
http://www.rush.edu/

More articles from Health and Medicine:

nachricht Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>