Most breast cancer patients with more than 10 nodes that are affected by the cancer have a poor prognosis, yet some survive long-term. Physicians now believe that certain genes in the breast cancer tissue, removed at diagnosis, can help them predict which patients will survive.
With this information, doctors can recommend the most appropriate therapy for an individual patient, for example sparing a woman with a poor prognosis the rigors that accompany aggressive chemotherapy, and enabling her to receive novel treatments that might work, according to Dr. Melody Cobleigh, oncologist, professor of medicine and director of the Comprehensive Breast Center at Rush-Presbyterian-St. Lukes Medical Center in Chicago.
Cobleigh presented her research results on May 31 at the American Society of Clinical Oncology Annual Meeting in Chicago. Until now, such studies could only be performed on recently biopsied tissue that would then be frozen for preservation. Routine handling of cancer specimens does not involve freezing. Cobleigh and colleagues at Genomic Health examined the breast cancer tissue of 79 patients who had been treated at Rush between 1979 and 1999 and whose tissues had been processed in the usual manner (formalin-fixed and paraffin-embedded). The patients had been followed for a median of 15 years.
Chris Martin | EurekAlert!
23.03.2017 | Technische Universität München
How prenatal maternal infections may affect genetic factors in Autism spectrum disorder
22.03.2017 | University of California - San Diego
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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