Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Antibody coated stent a breakthrough in cardiovascular treatment

22.05.2003


An innovative medical discovery that has the potential to vastly improve the lives of people suffering from coronary artery disease was implanted today in the first human patient. The antibody coated stent, developed by Dr. Michael Kutryk, a cardiologist and clinician scientist with St. Michael’s Hospital and assistant professor, University of Toronto, was implanted into the first human patient at Thoraxcenter, University Hospital Rotterdam in Holland. The procedure was transmitted via a live feed to the EuroPCR Conference in Paris, France - a conference of over 10,000 interventional cardiologists.



Stents are wire mesh tubes that have been used for years in interventional cardiology to clear blocked arteries and to improve the flow of blood to the heart muscle. However, traditional stents have been known to cause restenosis (re-narrowing of the artery in a treated area) and can lead to blood clots. Kutryk’s invention of the antibody coated stent reduces restenosis and prevents blood clots from occurring.

"This is a very exciting time to be working in the field of interventional cardiology," says Dr. Kutryk. "When animal trials showed that antibody coated stents were successful in promoting healing and preventing restenosis, we knew this could potentially impact a large number of patients suffering from coronary artery disease."


"If the implantation of the coated stent works in humans like it has in animals, it will be one of the biggest advances in cardiology we have seen to date," says Dr. Patrick Serruys, cardiologist, University Hospital Rotterdam. "We have been calling Dr. Kutryk’s research a glimpse into the future. Today, that future is here."

When placed into a blocked area of an artery, the antibody coated stent captures endothelial progenitor cells (EPC) circulating throughout the blood. Endothelial cells are cells which line blood vessels, allowing blood to flow smoothly.

The EPCs adhere to the hard surface of the stent forming a smooth layer that not only promotes healing but prevents restenosis (re-narrowing of the artery) and blood clots, complications previously associated with the use of stents.

"We are expecting to perform the first operation of a stent on a North American patient at St. Michael’s Hospital sometime in early June," said Kutryk. "Once we determine the effectiveness of using the antibody coated stents, we will be examining other ways that this discovery can be used to improve clinical outcomes for patients suffering from cardiovascular disease. The implications are enormous."

In addition to improving outcomes for patients requiring stents, there are also implications for patients requiring cardiovascular bypass surgery. For example, a prosthetic vascular conduit (artificial artery) coated with anti-EPC antibodies would eliminate the need to use arteries from patients legs or arms for bypass surgery grafts. This would reduce surgery and anesthesia times which in turn will reduce coronary surgery deaths.

According to the Heart and Stroke Foundation of Canada cardiovascular disease accounted for 78,942 Canadian deaths in 1999 with 54 per cent of cardiovascular deaths from coronary artery disease and an additional 10 per cent of deaths from high blood pressure and hardening of the arteries.

Dr. Kutryk’s research is supported by a grant from ORBUS medical technologies. The company contributed funding the research, but had no input or influence over the research or conduct.

St. Michael’s Hospital is a Catholic teaching and research hospital, fully affiliated with the University of Toronto, specializing in heart and vascular disease, inner city health, trauma/neurosurgery, diabetes comprehensive care, minimal access therapeutics, and neurological and musculoskeletal disorders.


For more information please contact:

Tracy MacIsaac, Media Relations
St. Michael’s Hospital
Telephone: 416-864-5047
Pager: 416-864-5431

Jessica Villanueva, Media Relations
St. Michael’s Hospital
Telephone: 416-864-5034
Pager: 416-864-5431

Tracy MacIsaac | EurekAlert!
Further information:
http://www.utoronto.ca/

More articles from Health and Medicine:

nachricht NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University

nachricht How to turn white fat brown
07.12.2016 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

NTU scientists build new ultrasound device using 3-D printing technology

07.12.2016 | Health and Medicine

The balancing act: An enzyme that links endocytosis to membrane recycling

07.12.2016 | Life Sciences

How to turn white fat brown

07.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>