Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Antibody coated stent a breakthrough in cardiovascular treatment

22.05.2003


An innovative medical discovery that has the potential to vastly improve the lives of people suffering from coronary artery disease was implanted today in the first human patient. The antibody coated stent, developed by Dr. Michael Kutryk, a cardiologist and clinician scientist with St. Michael’s Hospital and assistant professor, University of Toronto, was implanted into the first human patient at Thoraxcenter, University Hospital Rotterdam in Holland. The procedure was transmitted via a live feed to the EuroPCR Conference in Paris, France - a conference of over 10,000 interventional cardiologists.



Stents are wire mesh tubes that have been used for years in interventional cardiology to clear blocked arteries and to improve the flow of blood to the heart muscle. However, traditional stents have been known to cause restenosis (re-narrowing of the artery in a treated area) and can lead to blood clots. Kutryk’s invention of the antibody coated stent reduces restenosis and prevents blood clots from occurring.

"This is a very exciting time to be working in the field of interventional cardiology," says Dr. Kutryk. "When animal trials showed that antibody coated stents were successful in promoting healing and preventing restenosis, we knew this could potentially impact a large number of patients suffering from coronary artery disease."


"If the implantation of the coated stent works in humans like it has in animals, it will be one of the biggest advances in cardiology we have seen to date," says Dr. Patrick Serruys, cardiologist, University Hospital Rotterdam. "We have been calling Dr. Kutryk’s research a glimpse into the future. Today, that future is here."

When placed into a blocked area of an artery, the antibody coated stent captures endothelial progenitor cells (EPC) circulating throughout the blood. Endothelial cells are cells which line blood vessels, allowing blood to flow smoothly.

The EPCs adhere to the hard surface of the stent forming a smooth layer that not only promotes healing but prevents restenosis (re-narrowing of the artery) and blood clots, complications previously associated with the use of stents.

"We are expecting to perform the first operation of a stent on a North American patient at St. Michael’s Hospital sometime in early June," said Kutryk. "Once we determine the effectiveness of using the antibody coated stents, we will be examining other ways that this discovery can be used to improve clinical outcomes for patients suffering from cardiovascular disease. The implications are enormous."

In addition to improving outcomes for patients requiring stents, there are also implications for patients requiring cardiovascular bypass surgery. For example, a prosthetic vascular conduit (artificial artery) coated with anti-EPC antibodies would eliminate the need to use arteries from patients legs or arms for bypass surgery grafts. This would reduce surgery and anesthesia times which in turn will reduce coronary surgery deaths.

According to the Heart and Stroke Foundation of Canada cardiovascular disease accounted for 78,942 Canadian deaths in 1999 with 54 per cent of cardiovascular deaths from coronary artery disease and an additional 10 per cent of deaths from high blood pressure and hardening of the arteries.

Dr. Kutryk’s research is supported by a grant from ORBUS medical technologies. The company contributed funding the research, but had no input or influence over the research or conduct.

St. Michael’s Hospital is a Catholic teaching and research hospital, fully affiliated with the University of Toronto, specializing in heart and vascular disease, inner city health, trauma/neurosurgery, diabetes comprehensive care, minimal access therapeutics, and neurological and musculoskeletal disorders.


For more information please contact:

Tracy MacIsaac, Media Relations
St. Michael’s Hospital
Telephone: 416-864-5047
Pager: 416-864-5431

Jessica Villanueva, Media Relations
St. Michael’s Hospital
Telephone: 416-864-5034
Pager: 416-864-5431

Tracy MacIsaac | EurekAlert!
Further information:
http://www.utoronto.ca/

More articles from Health and Medicine:

nachricht Improving memory with magnets
28.03.2017 | McGill University

nachricht Graphene-based neural probes probe brain activity in high resolution
28.03.2017 | Graphene Flagship

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Transport of molecular motors into cilia

28.03.2017 | Life Sciences

A novel hybrid UAV that may change the way people operate drones

28.03.2017 | Information Technology

NASA spacecraft investigate clues in radiation belts

28.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>