Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Chemical in Broccoli Blocks Growth of Prostate Cancer Cells, New Study Shows

16.05.2003


Those seeking yet another reason to eat their veggies, take note. Researchers at the University of California, Berkeley, have found that a chemical produced when digesting such greens as broccoli and kale can stifle the growth of human prostate cancer cells.


Research shows that a chemical derived from cruciferous vegetables like broccoli could be effective against the growth of prostate cancer cells.



The findings show that 3,3’-diindolylmethane (DIM), which is obtained by eating cruciferous vegetables in the Brassica genus, acts as a powerful anti-androgen that inhibits the proliferation of human prostate cancer cells in culture tests.
Research shows that a chemical derived from cruciferous vegetables like broccoli could be effective against the growth of prostate cancer cells.

"As far as we know, this is the first plant-derived chemical discovered that acts as an anti-androgen," said Leonard Bjeldanes, professor and chair of nutritional sciences and toxicology at UC Berkeley’s College of Natural Resources and principal investigator of the study. "This is of considerable interest in the development of therapeutics and preventive agents for prostate cancer."



Vegetables such as broccoli, Brussels sprouts, kale and cauliflower are rich sources of indole-3-carbinol (I3C), which the body converts into DIM during digestion. Over the years, Bjeldanes has been researching the anti-cancer properties of dietary indoles with co-author Gary Firestone, UC Berkeley professor of molecular and cell biology.

The new study will be published in the June 6 issue of the Journal of Biological Chemistry, but is now available online.

Androgen is an important hormone for the normal development and function of the prostate, but it also plays a key role in the early stages of prostate cancer, which is typically treated with anti-androgen drugs.

In most cases of prostate cancer, the cancer cells develop resistance to androgen and grow independently of the hormone in later stages of the disease.

In the new study, the researchers conducted a series of tests comparing the effects of DIM on androgen-dependent human prostate cancer cells as well as on their androgen-independent counterparts.

They found that androgen-dependent cancer cells treated with a solution of DIM grew 70 percent less than the same type of cancer cells that had been left untreated. The same solution had no effect on the growth of androgen-independent cells, pointing to androgen inhibition as the key mechanism by which the DIM is acting.

This was confirmed with further tests showing that DIM inhibits the actions of dihydrotestosterone (DHT), the primary androgen involved in prostate cancer. DHT stimulates the expression of prostate specific antigen (PSA), which acts as a growth factor for prostate cancer. When androgen-dependent cells were treated with DIM, the researchers found a drop in the level of PSA.

"There are lots of things that can stop growth, but the fact that DIM decreases the expression of PSA shows that it is functioning at a gene expression level," said Bjeldanes.

Comparisons of the molecular conformation of DIM show that it is similar to Casodex, a synthetic anti-androgen on the market. "DIM works by binding to the same receptor that DHT uses, so it’s essentially blocking the androgen from triggering the growth of the cancer cells," said Hien Le, lead author of the study and a former graduate student in Bjeldanes’ lab.

"DIM is chemically different than Casodex, but it behaves similarly in how it blocks the effects of androgen," said Le, who received her PhD in molecular and biochemical nutrition in 2002.

These latest findings appear to add new burnish for this class of chemicals that has already shown promise in prior studies as a therapeutic agent for breast and endometrial cancer. For instance, a 1998 study by Bjeldanes and Firestone showed that I3C keeps breast cancer cells from duplicating.

"We are investigating the potential use of indoles in combination with current anti-cancer drugs on the market," said Firestone. "The advantage of combination therapy is that you can back off on the dose of a single agent and thereby reduce potential side effects."

Prostate cancer is the second leading cause of cancer deaths in American men. One in 10 men in the United States will develop signs of prostate cancer in his life, and more than 100,000 new cases are reported each year.

Le pointed out that the incidence of prostate cancer among men in Asia - where consumption of vegetables is higher - is significantly lower than that for men in the United States. However, the risk for Asian immigrants rises to levels comparable to American men the longer they stay in the United States, suggesting that factors such as diet and lifestyle play a role in the development of prostate cancer.

"There are already plenty of health reasons for consuming more vegetables such as broccoli," said Le. "This study suggests that there are even more benefits to a diet rich in these phytochemicals when it comes to preventing prostate cancer."

The study was also co-authored by Charlene Schaldach, a former PhD student in the Bjeldanes lab.

The research is supported by the California Cancer Research Project and the National Institute of Environmental Health Sciences, part of the National Institutes of Health.

Sarah Yang | UC Berkeley News
Further information:
http://www.berkeley.edu/news/media/releases/2003/05/12_Cancer.shtml

More articles from Health and Medicine:

nachricht Fast-tracking T cell therapies with immune-mimicking biomaterials
16.01.2018 | Wyss Institute for Biologically Inspired Engineering at Harvard

nachricht Dengue takes low and slow approach to replication
12.01.2018 | Duke University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

White graphene makes ceramics multifunctional

16.01.2018 | Materials Sciences

Breaking bad metals with neutrons

16.01.2018 | Materials Sciences

ISFH-CalTeC is “designated test centre” for the confirmation of solar cell world records

16.01.2018 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>