Fatal, electrical chaos can develop in the hearts of otherwise healthy people who produce a defective accessory protein called ankyrin-B, reports W. Jonathan Lederer of the University of Maryland Biotechnology Institute (UMBI) and collaborators, in the February 6 issue of the scientific journal Nature.
By discovering the molecular and cellular causes of the electrical chaos-known as Long QT Syndrome Type 4, or LQT4-Lederer and collaborators open the door to possible therapies and diagnostics for this and related heart diseases. The work also provides a clue to how important, specific proteins are organized within heart cells.
Several years ago, clinical researchers in France, headed by Denis Escande, discovered an inheritance pattern in members of a family who had been dying suddenly and unexpectedly in the prime of life. Lederers team at UMBI and the University of Maryland at Baltimore and researchers at Duke University, headed by Vann Bennett, collaborated with the French by applying state-of-the-art heart physiology tools to mouse heart cells in order to find the cause of the sudden deaths.
Steve Berberich | EurekAlert!
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Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
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