Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

AIDS vaccine developed at Emory and the NIH Moves to clinical trials

24.01.2003


A vaccine aimed against AIDS, developed at the Yerkes National Primate Research Center of Emory University, the Emory Vaccine Center, and the Laboratory of Viral Diseases at the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH), will begin a Phase I clinical trial this week.



A total of 30 human volunteers will be enrolled at the University of Alabama at Birmingham, the University of Washington in Seattle, and the San Francisco Department of Public Health. The trial is funded by NIAID and is conducted by the HIV Vaccine Trials Network, located at the Fred Hutchinson Cancer Research Center in Seattle, Wash.

Developed by virologists Harriet L. Robinson, PhD, James M. Smith, PhD, Bernard Moss, MD, PhD, and Linda Wyatt, PhD, the vaccine strategy employs two different components: two inoculations of a DNA vaccine that primes the immune system to recognize HIV; and a subsequent booster vaccine based on a recombinant poxvirus. Neither component incorporates the actual virus; instead, the vaccine produces the three major proteins expressed by HIV. In essence, the vaccine induces the immune system to respond to the distinguishing features of HIV so the system will respond to the actual virus should it appear.


This first clinical trial, which will last one year, will focus on assessing the safety of the DNA primer vaccine among HIV-negative volunteers, who will be randomly assigned to receive one of the following: high-dose vaccine, low-dose vaccine, or placebo. A second, separate clinical trial will focus on the safety of the booster vaccine.

"We will have a third Phase I trial to test the combined regimen of the DNA and booster portions of the vaccine strategy," said Dr. Robinson, who is chief of the Yerkes Division of Microbiology and Immunology and a faculty member of the Emory Vaccine Center. As Robinson and her colleagues reported in Science in 2001, in a study involving 24 rhesus macaque monkeys, the prime-boost vaccine strategy successfully contained infection and prevented progression to AIDS. According to a subsequent Yerkes study reported in October 2002 in the Journal of Virology, levels of viral RNA and DNA in the monkeys have declined to the nearly undetectable levels characteristic of a small subset of HIV-infected people, termed long-term non-progressors, who are infected with HIV but do not develop AIDS.

"It is important to remember that this clinical trial represents the culmination of years of work in basic science and preclinical studies involving animal models that have greatly expanded our knowledge of immunology," said Vaccine Center Director Rafi Ahmed, PhD. "Every new AIDS vaccine candidate that enters human studies brings us closer to understanding HIV and the human immune system – and to ending the worldwide AIDS pandemic."

The experimental vaccine is licensed from Emory by GeoVax, Inc., a company founded by Emory University and the Emory Vaccine Center to manufacture the vaccine.


The Yerkes National Primate Research Center of Emory University is one of eight National Primate Research Centers funded by the National Institutes of Health. The Yerkes Center is a multidisciplinary research institute recognized as a leader in biomedical and behavioral studies with non-human primates. Yerkes scientists are on the forefront of developing vaccines for AIDS and malaria, and treatments for cocaine addiction, Parkinson’s disease and cardiovascular disease. Other research programs include cognitive development and decline, childhood visual defects, organ transplant rejection and social behaviors of primates. Leading researchers located worldwide seek to collaborate with Yerkes scientists.

The mission of the Emory Vaccine Center is to create new technologies for the prevention of emerging infectious diseases, by conducting basic and translational research and clinical trials. The Vaccine Center was established in 1996 with support from Emory University and the Georgia Research Alliance.

GeoVax, Inc. is developing products related to the research described above. Under an agreement between GeoVax, Inc. and Emory University, the inventors are entitled to a share of sales royalty received by Emory University from GeoVax. Under that agreement, Emory University has received GeoVax equity interests. Dr. Robinson is also Chairman of the Scientific Advisory Board and a minor equity holder in GeoVax. The terms of this arrangement have been reviewed and approved by the University in accordance with its conflict of interest policies.


Holly Korschun | EurekAlert!
Further information:
http://www.emory.edu/

More articles from Health and Medicine:

nachricht A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital

nachricht Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

DGIST develops 20 times faster biosensor

24.04.2017 | Physics and Astronomy

Nanoimprinted hyperlens array: Paving the way for practical super-resolution imaging

24.04.2017 | Materials Sciences

Atomic-level motion may drive bacteria's ability to evade immune system defenses

24.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>