Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New drug linked to fewer deaths among kidney patients undergoing hemodialysis

04.11.2002


University of North Carolina at Chapel Hill researchers report a 50 percent reduction in the number of deaths among kidney hemodialysis patients who are given a new drug that helps prevent excess phosphorus from accumulating in the bloodstream. "The drug, lanthanum carbonate, is effective. It’s well-tolerated, and patients find it reasonably easy to take," said Dr. William Finn, nephrologist and professor of medicine at UNC.



Study findings will be presented Saturday (Nov. 2) at the American Society of Nephrology annual meeting in Philadelphia. More than 350,000 people in the United States receive treatment for kidney failure, or end-stage renal disease, according to the National Institutes of Health. Of these, about 60 percent undergo hemodialysis, a process that removes wastes and excess fluid from the bloodstream by passing it through a membrane in an artificial kidney machine.

Although regular hemodialysis treatment helps maintain life, studies show it provides about a tenth of the cleaning function of normal kidneys. Moreover, those on the treatment run an increased risk of cardiovascular disease and other medical problems. "One of the things hemodialysis does not do well is remove phosphorus from the blood," Finn said. "About 50 to 60 percent of patients on chronic hemodialysis do not have adequate phosphorus control; they have high phosphorus levels."


Finn added that elevated blood levels of phosphorus help trigger hyperparathyroidism, a condition that may lead to serious bone and cardiovascular problems. Some research indicates an increased risk for cardiac death possibly due to a buildup of calcium in coronary blood vessels.

Moreover, beginning in 1998, reports in medical literature have identified elevated phosphorus blood levels as independent risk factors for mortality among kidney patients on hemodialysis. The National Kidney Foundation has subsequently lowered its recommended phosphorus blood levels.

Today, many kidney failure patients undergoing hemodialysis take medications that bind dietary phosphorus, thereby allowing its excretion in the stool rather than its absorption by the body.

Originally, aluminum hydroxide or aluminum containing compounds were used "because aluminum binds phosphorus very well," Finn said. "Unfortunately, some of the aluminum was absorbed and found its way into bone and brain tissue, causing serious bone disease and a condition known as dialysis dementia."

Other phosphorus or phosphate binding agents were then used, including calcium carbonate (a main ingredient in popular stomach relievers) and calcium acetate. However, some patients using these calcium-based binders develop hypercalcemia, high calcium levels, prompting a search for other types of phosphate binders.

Recently, a non-calcium phosphate binder, Renagel, has come into use. Its maker, Genzyme Corp., sponsored a major clinical study in which hemodialysis patients taking their drug showed less coronary artery calcification than did patients taking calcium-based phosphate binders. However, differences in cardiac mortality among patients in the different drug group binders were not demonstrated in that study, Finn said. A separate study addressing this issue is under way.

The UNC investigation involves the newly developed, non-calcium phosphate binder, lanthanum carbonate (Fosrenol), developed by Shire Pharmaceuticals Group, PLC, in the United Kingdom and not yet federally approved for use in the United States.

Lanthanum is a rare earth element, a heavy metal that binds phosphorus. Results of a study of bone biopsies in the United States and Europe earlier this year found no abnormalities, Finn said.

"In addition, there’s no evidence that lanthanum crosses the blood-brain barrier. Tests of cognitive function are being used to determine any central nervous system changes with Fosrenol use."

In the randomized two-year study, 647 kidney hemodialysis patients received lanthanum carbonate therapy and 642 patients received conventional phosphate binders. Patients ranged in age from 19 to 91 years. The first interim analysis indicated a reduction in mortality in the Fosrenol group, compared to those taking conventional drug therapy. A second interim analysis indicated a widening disparity with a reduction in mortality, 3.3 percent versus 5.8 percent. Moreover, fewer people died of what appear to be cardiac factors.

"I think this drug, Fosrenol, or drugs like it will become the preferred phosphate binders," Finn said.


Note: Contact Finn at 215-625-2900 between Thursday (Oct. 31) and Saturday (Nov. 2). Otherwise, contact him at 919-966-2561, ext. 226, or wffinn@med.unc.edu.

School of Medicine contact: Les Lang, 919-843-9687 or llang@med.unc.edu


Leslie H. Lang | EurekAlert!
Further information:
http://www.med.unc.edu/

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>