Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Prototype developed for ultrasonic patch to deliver insulin

23.10.2002


Penn State engineers have developed a prototype for an ultrasound insulin delivery system that is about the size and weight of a matchbook that can be worn as a patch on the body.



Dr. Nadine Barrie Smith, assistant professor of bioengineering, says, "The new Penn State ultrasound patch, which operates in the same frequency range as the large commercially available sonic drug delivery devices, is about an inch-and-a-half by an inch-and-a-half in size and weighs less than an ounce. Commercially available sonicators currently have a probe about eight inches long which weighs over two pounds."

Experiments with human skin and with live rats have shown that the new ultrasound patch delivers therapeutically effective doses of insulin.


The new prototype is described in detail in "Transducer Design for a Portable Ultrasound Enhanced Transdermal Drug-Delivery System," published in the current (October) issue of the IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

The key to the new ultrasound patch is a "cymbal" transducer developed by Dr. Robert Newnham, the Alcoa professor emeritus of solid state science. The transducer produces the sound waves that drive the medication through the skin and into the blood stream. The cymbal transducer consists of a thin disk of piezoelectric ceramic material sandwiched between titanium end caps shaped like cymbals. Four of these transducers are used in the prototype.

A thin reservoir of insulin is placed in front of the cymbal transducer and when a current is applied, sound waves just above the level of human hearing push the medication through the skin and into the blood vessels.

Smith notes, "Our experiments with rats show that an exposure of 20 minutes produced the same result as a 60-minute exposure. So, we are hopeful that, eventually, we may be able to tune the system so that one to five minutes of exposure may be enough."

Currently, diabetics must either inject insulin via hypodermic needles or use a mini-pump with a catheter that remains implanted in their body. Ultrasound offers a less painful and invasive alternative.

Besides insulin, some medications used to treat AIDS, pain relievers, asthma drugs, and hormones are deliverable via ultrasound, Smith adds. Those medications and, perhaps, some others that cannot be taken by mouth, are candidates for administration via the new ultrasound patch.


Her co-authors are Emiliano Maione, graduate student; Dr. K. Kirk Shung, professor of bioengineering; Dr. Richard J. Meyer, research associate at Penn State’s Applied Research Laboratory (ARL); Dr. Jack W. Hughes, ARL Senior scientist and professor of acoustics; Newnham; and Smith. The rat experiments are described in "Ultrasound Mediated Transdermal in vivo Transport of Insulin with Low Profile Cymbal Arrays," presented this month at the IEEE 2002 Ultrasonics Symposium in Munich, Germany. The authors are Seungjun Lee, graduate student, Smith and Shung.

The research was supported, in part, with laboratory start-up funds provided to Smith by the University.

Barbara Hale | EurekAlert!
Further information:
http://www.psu.edu/

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>