Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Prototype developed for ultrasonic patch to deliver insulin

23.10.2002


Penn State engineers have developed a prototype for an ultrasound insulin delivery system that is about the size and weight of a matchbook that can be worn as a patch on the body.



Dr. Nadine Barrie Smith, assistant professor of bioengineering, says, "The new Penn State ultrasound patch, which operates in the same frequency range as the large commercially available sonic drug delivery devices, is about an inch-and-a-half by an inch-and-a-half in size and weighs less than an ounce. Commercially available sonicators currently have a probe about eight inches long which weighs over two pounds."

Experiments with human skin and with live rats have shown that the new ultrasound patch delivers therapeutically effective doses of insulin.


The new prototype is described in detail in "Transducer Design for a Portable Ultrasound Enhanced Transdermal Drug-Delivery System," published in the current (October) issue of the IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

The key to the new ultrasound patch is a "cymbal" transducer developed by Dr. Robert Newnham, the Alcoa professor emeritus of solid state science. The transducer produces the sound waves that drive the medication through the skin and into the blood stream. The cymbal transducer consists of a thin disk of piezoelectric ceramic material sandwiched between titanium end caps shaped like cymbals. Four of these transducers are used in the prototype.

A thin reservoir of insulin is placed in front of the cymbal transducer and when a current is applied, sound waves just above the level of human hearing push the medication through the skin and into the blood vessels.

Smith notes, "Our experiments with rats show that an exposure of 20 minutes produced the same result as a 60-minute exposure. So, we are hopeful that, eventually, we may be able to tune the system so that one to five minutes of exposure may be enough."

Currently, diabetics must either inject insulin via hypodermic needles or use a mini-pump with a catheter that remains implanted in their body. Ultrasound offers a less painful and invasive alternative.

Besides insulin, some medications used to treat AIDS, pain relievers, asthma drugs, and hormones are deliverable via ultrasound, Smith adds. Those medications and, perhaps, some others that cannot be taken by mouth, are candidates for administration via the new ultrasound patch.


Her co-authors are Emiliano Maione, graduate student; Dr. K. Kirk Shung, professor of bioengineering; Dr. Richard J. Meyer, research associate at Penn State’s Applied Research Laboratory (ARL); Dr. Jack W. Hughes, ARL Senior scientist and professor of acoustics; Newnham; and Smith. The rat experiments are described in "Ultrasound Mediated Transdermal in vivo Transport of Insulin with Low Profile Cymbal Arrays," presented this month at the IEEE 2002 Ultrasonics Symposium in Munich, Germany. The authors are Seungjun Lee, graduate student, Smith and Shung.

The research was supported, in part, with laboratory start-up funds provided to Smith by the University.

Barbara Hale | EurekAlert!
Further information:
http://www.psu.edu/

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>