Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Antioxidant Reduces Brain Damage in Stroke Model

01.10.2002


New research shows that a synthetic antioxidant can reduce brain damage by more than 40 percent in an animal model of stroke when given seven and a half hours after the stroke begins. Researchers at National Jewish Medical and Research Center and Duke University Medical Center will report their findings in the October issue of the journal Free Radical Biology and Medicine.



"Because the onset of a stroke can be difficult to detect, many patients do not get treatment for several hours," said James Crapo, M.D., co-author and Chairman of the Department of Medicine at National Jewish. "Our findings suggest that the antioxidant is a promising candidate for stroke therapy because it can prevent damage so many hours after the stroke begins."

Strokes occur when blood supply to the brain is interrupted because blood vessels in the brain either leak or are blocked. Starved of oxygen, the brain cells die. However, cell death continues to occur for many hours, even after blood flow is returned to the brain. Many of the cells that are injured, but not killed by oxygen deprivation, die in the hours following the stroke. Free radicals, highly reactive molecules, kill many of those cells.


The researchers used a synthetic antioxidant, known as AEOL 10150, to neutralize the damaging free radicals and reduce cell death in a mouse model of stroke. AEOL 10150, developed by Dr. Crapo and his colleagues at Duke, mimics the naturally occurring antioxidant superoxide dismutase, but is effective against a wider range of oxygen radicals and lasts longer in the body. Now licensed by Incara Pharmaceuticals Corporation, it has shown promise in preventing damage to cells caused by diabetes and radiation therapy for cancer.

The researchers blocked the middle cerebral artery of rats for 90 minutes. They then injected AEOL 10150 or a placebo into the brains of these mice six hours after the artery had been reopened. The six-hour post-stroke time period has significant clinical relevance. In an unrelated stroke study, 26 percent of patients received treatment within four hours, but 99 percent received treatment within six hours.

When evaluated a week later, animals who received the placebo had an average of 160 cubic millimeters of brain tissue destroyed by the stroke. Animals who received the antioxidant had an average of 92 cubic millimeters of brain tissue destroyed by the stroke, 43 percent less than that the rats who received the placebo.

"There is a significant arc of potentially salvageable tissue surrounding the cells that are killed by the initial stroke," said David S. Warner, M.D., professor of anesthesiology at Duke University Medical Center. "The antioxidant appears to protect this tissue."

The researchers also treated mice with intravenous injections of the antioxidant. Although, this method produced a smaller effect, it reduced both tissue damage and neurological deficit, demonstrating the compound’s ability to cross the blood-brain barrier. Mechanistic studies also showed that the antioxidant significantly altered inflammatory gene expression in tissue.

William Allstetter | EurekAlert!
Further information:
http://www.njc.org/

More articles from Health and Medicine:

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>