Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Antioxidant Reduces Brain Damage in Stroke Model

01.10.2002


New research shows that a synthetic antioxidant can reduce brain damage by more than 40 percent in an animal model of stroke when given seven and a half hours after the stroke begins. Researchers at National Jewish Medical and Research Center and Duke University Medical Center will report their findings in the October issue of the journal Free Radical Biology and Medicine.



"Because the onset of a stroke can be difficult to detect, many patients do not get treatment for several hours," said James Crapo, M.D., co-author and Chairman of the Department of Medicine at National Jewish. "Our findings suggest that the antioxidant is a promising candidate for stroke therapy because it can prevent damage so many hours after the stroke begins."

Strokes occur when blood supply to the brain is interrupted because blood vessels in the brain either leak or are blocked. Starved of oxygen, the brain cells die. However, cell death continues to occur for many hours, even after blood flow is returned to the brain. Many of the cells that are injured, but not killed by oxygen deprivation, die in the hours following the stroke. Free radicals, highly reactive molecules, kill many of those cells.


The researchers used a synthetic antioxidant, known as AEOL 10150, to neutralize the damaging free radicals and reduce cell death in a mouse model of stroke. AEOL 10150, developed by Dr. Crapo and his colleagues at Duke, mimics the naturally occurring antioxidant superoxide dismutase, but is effective against a wider range of oxygen radicals and lasts longer in the body. Now licensed by Incara Pharmaceuticals Corporation, it has shown promise in preventing damage to cells caused by diabetes and radiation therapy for cancer.

The researchers blocked the middle cerebral artery of rats for 90 minutes. They then injected AEOL 10150 or a placebo into the brains of these mice six hours after the artery had been reopened. The six-hour post-stroke time period has significant clinical relevance. In an unrelated stroke study, 26 percent of patients received treatment within four hours, but 99 percent received treatment within six hours.

When evaluated a week later, animals who received the placebo had an average of 160 cubic millimeters of brain tissue destroyed by the stroke. Animals who received the antioxidant had an average of 92 cubic millimeters of brain tissue destroyed by the stroke, 43 percent less than that the rats who received the placebo.

"There is a significant arc of potentially salvageable tissue surrounding the cells that are killed by the initial stroke," said David S. Warner, M.D., professor of anesthesiology at Duke University Medical Center. "The antioxidant appears to protect this tissue."

The researchers also treated mice with intravenous injections of the antioxidant. Although, this method produced a smaller effect, it reduced both tissue damage and neurological deficit, demonstrating the compound’s ability to cross the blood-brain barrier. Mechanistic studies also showed that the antioxidant significantly altered inflammatory gene expression in tissue.

William Allstetter | EurekAlert!
Further information:
http://www.njc.org/

More articles from Health and Medicine:

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>