The average persons heart pumps about a gallon of blood per minute, a rate that can easily triple or quadruple during exercise.
The rapid flow of blood through the body is a major roadblock to the use of gene therapy to cure diseases. When injected into the blood, vector viruses – which carry corrective genes – tend to shoot past the target organ or tissue rather than sticking to it, like grains of sand moving past stones in a fast-flowing river.
Now, University of Florida gene therapy and biomedical engineering researchers have demonstrated a novel approach to the problem. In a July article in Molecular Therapy, they report attaching the adeno-associated virus, a widely used gene carrier, to the surface of tiny manufactured balls known as microspheres, each containing a miniscule particle of iron oxide. Using a magnet placed under culture dishes, the researchers were able to coax large amounts of the microspheres to target areas of the cultures. In related experiments in mice, the researchers showed the microspheres clung to cells or organs longer than the virus alone did.
Barry Byrne | EurekAlert!
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MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
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