Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Developments in Angiogenic Therapy Emerging from Oxford

26.08.2002


Angiogenesis, the growth of new blood vessels, is important in the healthy body for healing wounds and, in females, for the monthly reproductive cycle and during pregnancy. It is controlled in the body through the use of the body’s own angiogenesis inhibitors and stimulators. In certain diseases the body is unable to control blood vessel growth. In diseases such as cancer, diabetic blindness and psoriasis, excessive angiogenesis is occurring; and in diseases such as coronary artery disease and stroke insufficient angiogenesis is the problem.



A novel anti-angiogenic agent

Researchers in the Cancer Research UK Molecular Oncology Laboratory at Oxford University have now identified a new inhibitor of endothelial cell proliferation with possible applications in the treatment of those disorders listed above which are characterised by excessive angiogenesis.


For example, solid cancer tumours are often characterised as being angiogenic, i.e. having an increased blood supply. One promising new treatment for solid tumours proposes to cut off the tumour’s blood supply with subsequent tumour shrinkage. Endothelial cells that line normal blood vessels are usually quiescent while those within tumour blood vessels are proliferating. Anti-angiogenic agents that can selectively inhibit proliferating endothelial cells or cytotoxic agents that can be delivered to the tumour vasculature have huge potential for the treatment of solid tumours.

Oxford, Imperial College and Cancer Research UK scientists, led by Professor Adrian Harris, have now identified a new agent for solving this problem. An anti-angiogenic peptide has been isolated and characterised. This peptide is a new member of the family of anti-angiogenic molecules that includes angiostatin which have for some years been of great interest to the pharmaceutical community. It has been shown in experiments to be an effective inhibitor of endothelial cell proliferation.

A new lead in the fight against Coronary Artery Disease

Alternatively, it has been found that the antibody to the peptide is effective in promoting the proliferation of endothelial cells and is thus a potential angiogenic agent for the treatment of disorders such as coronary artery disease. Angiogenic therapy can alleviate coronary artery disease by stimulating new vessel growth and returning blood flow to the heart, through the delivery of angiogenic proteins or their genes to this organ. Endothelial cells that line blood vessels are the initial targets for promoting new vessel growth. Therefore new biological agents that can stimulate endothelial cell growth, such as this antibody, are important candidates for angiogenic therapy.

Isis Innovation, Oxford University’s technology transfer company, holds the patent application for this project and is actively seeking partners for the licensing and commercial development of these technologies.

Jennifer Johnson | alfa
Further information:
http://www.isis-innovation.com/licensing/779.html

More articles from Health and Medicine:

nachricht Nanoparticles as a Solution against Antibiotic Resistance?
15.12.2017 | Friedrich-Schiller-Universität Jena

nachricht Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>