Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Developments in Angiogenic Therapy Emerging from Oxford

26.08.2002


Angiogenesis, the growth of new blood vessels, is important in the healthy body for healing wounds and, in females, for the monthly reproductive cycle and during pregnancy. It is controlled in the body through the use of the body’s own angiogenesis inhibitors and stimulators. In certain diseases the body is unable to control blood vessel growth. In diseases such as cancer, diabetic blindness and psoriasis, excessive angiogenesis is occurring; and in diseases such as coronary artery disease and stroke insufficient angiogenesis is the problem.



A novel anti-angiogenic agent

Researchers in the Cancer Research UK Molecular Oncology Laboratory at Oxford University have now identified a new inhibitor of endothelial cell proliferation with possible applications in the treatment of those disorders listed above which are characterised by excessive angiogenesis.


For example, solid cancer tumours are often characterised as being angiogenic, i.e. having an increased blood supply. One promising new treatment for solid tumours proposes to cut off the tumour’s blood supply with subsequent tumour shrinkage. Endothelial cells that line normal blood vessels are usually quiescent while those within tumour blood vessels are proliferating. Anti-angiogenic agents that can selectively inhibit proliferating endothelial cells or cytotoxic agents that can be delivered to the tumour vasculature have huge potential for the treatment of solid tumours.

Oxford, Imperial College and Cancer Research UK scientists, led by Professor Adrian Harris, have now identified a new agent for solving this problem. An anti-angiogenic peptide has been isolated and characterised. This peptide is a new member of the family of anti-angiogenic molecules that includes angiostatin which have for some years been of great interest to the pharmaceutical community. It has been shown in experiments to be an effective inhibitor of endothelial cell proliferation.

A new lead in the fight against Coronary Artery Disease

Alternatively, it has been found that the antibody to the peptide is effective in promoting the proliferation of endothelial cells and is thus a potential angiogenic agent for the treatment of disorders such as coronary artery disease. Angiogenic therapy can alleviate coronary artery disease by stimulating new vessel growth and returning blood flow to the heart, through the delivery of angiogenic proteins or their genes to this organ. Endothelial cells that line blood vessels are the initial targets for promoting new vessel growth. Therefore new biological agents that can stimulate endothelial cell growth, such as this antibody, are important candidates for angiogenic therapy.

Isis Innovation, Oxford University’s technology transfer company, holds the patent application for this project and is actively seeking partners for the licensing and commercial development of these technologies.

Jennifer Johnson | alfa
Further information:
http://www.isis-innovation.com/licensing/779.html

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

Im Focus: Scientists improve forecast of increasing hazard on Ecuadorian volcano

Researchers from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science, the Italian Space Agency (ASI), and the Instituto Geofisico--Escuela Politecnica Nacional (IGEPN) of Ecuador, showed an increasing volcanic danger on Cotopaxi in Ecuador using a powerful technique known as Interferometric Synthetic Aperture Radar (InSAR).

The Andes region in which Cotopaxi volcano is located is known to contain some of the world's most serious volcanic hazard. A mid- to large-size eruption has...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

New thruster design increases efficiency for future spaceflight

16.08.2017 | Physics and Astronomy

Transporting spin: A graphene and boron nitride heterostructure creates large spin signals

16.08.2017 | Materials Sciences

A new method for the 3-D printing of living tissues

16.08.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>