New Developments in Angiogenic Therapy Emerging from Oxford
Angiogenesis, the growth of new blood vessels, is important in the healthy body for healing wounds and, in females, for the monthly reproductive cycle and during pregnancy. It is controlled in the body through the use of the body’s own angiogenesis inhibitors and stimulators. In certain diseases the body is unable to control blood vessel growth. In diseases such as cancer, diabetic blindness and psoriasis, excessive angiogenesis is occurring; and in diseases such as coronary artery disease and stroke insufficient angiogenesis is the problem.
A novel anti-angiogenic agent
Researchers in the Cancer Research UK Molecular Oncology Laboratory at Oxford University have now identified a new inhibitor of endothelial cell proliferation with possible applications in the treatment of those disorders listed above which are characterised by excessive angiogenesis.
For example, solid cancer tumours are often characterised as being angiogenic, i.e. having an increased blood supply. One promising new treatment for solid tumours proposes to cut off the tumour’s blood supply with subsequent tumour shrinkage. Endothelial cells that line normal blood vessels are usually quiescent while those within tumour blood vessels are proliferating. Anti-angiogenic agents that can selectively inhibit proliferating endothelial cells or cytotoxic agents that can be delivered to the tumour vasculature have huge potential for the treatment of solid tumours.
Oxford, Imperial College and Cancer Research UK scientists, led by Professor Adrian Harris, have now identified a new agent for solving this problem. An anti-angiogenic peptide has been isolated and characterised. This peptide is a new member of the family of anti-angiogenic molecules that includes angiostatin which have for some years been of great interest to the pharmaceutical community. It has been shown in experiments to be an effective inhibitor of endothelial cell proliferation.
A new lead in the fight against Coronary Artery Disease
Alternatively, it has been found that the antibody to the peptide is effective in promoting the proliferation of endothelial cells and is thus a potential angiogenic agent for the treatment of disorders such as coronary artery disease. Angiogenic therapy can alleviate coronary artery disease by stimulating new vessel growth and returning blood flow to the heart, through the delivery of angiogenic proteins or their genes to this organ. Endothelial cells that line blood vessels are the initial targets for promoting new vessel growth. Therefore new biological agents that can stimulate endothelial cell growth, such as this antibody, are important candidates for angiogenic therapy.
Isis Innovation, Oxford University’s technology transfer company, holds the patent application for this project and is actively seeking partners for the licensing and commercial development of these technologies.
Jennifer Johnson | alfa
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...