A new and somewhat controversial study published in the August issue of the Journal of Nuclear Medicine suggests that 18F-FDG PET results obtained after the first cycle of treatment can better predict progression-free survival in patients with aggressive non-Hodgkins lymphoma (NHL) or Hodgkins disease (HD) than PET scans conducted at the end of treatment.
Physicians at the Weill Medical College of Cornell and the New York Presbyterian Hospital in New York reported on 23 patients who received PET scans before and after one cycle of treatment and also at the completion of chemotherapy. PET was accurate 87% of the time after one cycle but only 70% of the time after completion of chemotherapy. Sensitivity, i.e., the ability to detect the FDG and hence disease, was also significantly higher after one cycle, at 82% v. 45.5%. In particular, in cases in which results from the first cycle differed from the results following completion of therapy, the results from the first cycle scan were more accurate. Ninety percent of patients with positive 18F-FDG PET results after one cycle experienced disease relapse, while 85% who had negative 18F-FDG PET findings after one cycle remained in remission. The authors concluded that PET was a better predictor of outcome and response to therapy after just one cycle of chemotherapy than after completion.
PET stands for positron emission tomography. Because of its unique ability to measure metabolic activity–or the efficiency of the cells converting food to energy--PET provides accurate, noninvasive detection and staging of many cancers. A radiopharmaceutical, such as 18F-FDG (fluorodeoxyglucose), which includes a radionuclide (a radioactive element) is injected into the patient and gives off signals that are measured by a PET scanner. Because cancer cells are more metabolically active, they show up on the PET images more intensely than normal tissue.
Karen Lubieniecki | EurekAlert!
Penn studies find promise for innovations in liquid biopsies
30.03.2017 | University of Pennsylvania School of Medicine
'On-off switch' brings researchers a step closer to potential HIV vaccine
30.03.2017 | University of Nebraska-Lincoln
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
30.03.2017 | Health and Medicine
30.03.2017 | Health and Medicine
30.03.2017 | Medical Engineering