For years, physicians have noticed surprising similarities in the factors that seem to trigger attacks in such episodic neurological disorders as migraine and dyskinesia. Common triggers include psychological stress, caffeine or alcohol ingestion, fatigue, hormonal fluctuations and exercise.
A new study shows that a mouse model can be used to investigate how these substances and environmental factors trigger symptomatic attacks. The researchers also identified two drugs that can prevent attacks of such disorders in mice.
The study is the first to use mice to investigate triggers of episodic attacks, which are much more difficult to study in humans. Though the symptoms of episodic disorders vary, the fact that many of them share the same trigger factors may suggest a common disease mechanism.
Tania Zeigler | EurekAlert!
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